Guidelines for Pediatric Unrelated Cord Blood Transplantation-Unique Considerations.
Abstract
Cord blood (CB) is the stem cell source of choice for approximately 30% of pediatric
patients undergoing hematopoietic cell transplantation. Cord blood is readily available
and is a particularly appealing stem cell source for patients who lack appropriate
HLA-matched related or unrelated donors. Pediatric cord blood transplant (CBT) recipients
have low rates of disease relapse in the malignant setting and very low rates of chronic
graft-versus-host disease (GVHD). In addition, CB has unique properties that make
it the stem cell source of choice for some nonmalignant conditions such as metabolic
disorders. This review provides evidence-based and experience-based pediatric-specific
guidelines for CBT including considerations for infectious disease management, CB
unit selection and infusion, conditioning regimen selection, and GVHD management.
In addition, it covers unique bedside considerations for pediatric patients and CB
banking. In concert with the other topic specific CB guidelines previously published
in this series, it provides a comprehensive overview of the clinical management of
pediatric CBT.
Type
Journal articleSubject
American Society for Transplantation and Cellular Therapy Cord Blood Special Interest
GroupFetal Blood
Humans
Graft vs Host Disease
Cord Blood Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation
Child
Unrelated Donors
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https://hdl.handle.net/10161/24570Published Version (Please cite this version)
10.1016/j.jtct.2021.09.013Publication Info
Dahlberg, Ann; Kurtzberg, Joanne; Boelens, Jaap; Martinez, Caridad; Carpenter, Paul;
Tewari, Priti; & American Society for Transplantation and Cellular Therapy Cord Blood
Special Interest Group (2021). Guidelines for Pediatric Unrelated Cord Blood Transplantation-Unique Considerations.
Transplantation and cellular therapy, 27(12). pp. 968-972. 10.1016/j.jtct.2021.09.013. Retrieved from https://hdl.handle.net/10161/24570.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Joanne Kurtzberg
Jerome S. Harris Distinguished Professor of Pediatrics
Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology,
pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation,
and novel applications of cord blood and birthing tissues in the emerging fields of
cellular therapies and regenerative medicine. Dr. Kurtzberg serves as the Director
of the Marcus Center for Cellular Cures (MC3), Director of the Pediatric Transplant
and Cellular Therapy Program, Director of the Carolina

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