Cord blood for brain injury.
Abstract
Recovery from neurological injuries is typically incomplete and often results in significant
and permanent disabilities. Currently, most available therapies are limited to supportive
or palliative measures, aimed at managing the symptoms of the condition. Because restorative
therapies targeting the underlying cause of most neurological diseases do not exist,
cell therapies targeting anti-inflammatory, neuroprotective and regenerative potential
hold great promise. Cord blood (CB) cells can induce repair through mechanisms that
involve trophic or cell-based paracrine effects or cellular integration and differentiation.
Both may be operative in emerging CB therapies for neurologic conditions, and there
are numerous potential applications of CB-based regenerative therapies in neurological
diseases, including genetic diseases of childhood, ischemic events such as stroke
and neurodegenerative diseases of adulthood. CB appears to hold promise as an effective
therapy for patients with brain injuries. In this Review, we describe the state of
science and clinical applications of CB therapy for brain injury.
Type
Journal articleSubject
Fetal BloodHumans
Brain Injuries
Nerve Degeneration
Cord Blood Stem Cell Transplantation
Clinical Trials as Topic
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https://hdl.handle.net/10161/24648Published Version (Please cite this version)
10.1016/j.jcyt.2015.03.004Publication Info
Sun, Jessica M; & Kurtzberg, Joanne (2015). Cord blood for brain injury. Cytotherapy, 17(6). pp. 775-785. 10.1016/j.jcyt.2015.03.004. Retrieved from https://hdl.handle.net/10161/24648.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Joanne Kurtzberg
Jerome S. Harris Distinguished Professor of Pediatrics
Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology,
pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation,
and novel applications of cord blood and birthing tissues in the emerging fields of
cellular therapies and regenerative medicine. Dr. Kurtzberg serves as the Director
of the Marcus Center for Cellular Cures (MC3), Director of the Pediatric Transplant
and Cellular Therapy Program, Director of the Carolina
Jessica Muller Sun
Assistant Professor of Pediatrics
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