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Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.

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Date
2014-06
Authors
Hitzler, Johann K
He, Wensheng
Doyle, John
Cairo, Mitchell
Camitta, Bruce M
Chan, Ka Wah
Diaz Perez, Miguel A
Fraser, Christopher
Gross, Thomas G
Horan, John T
Kennedy-Nasser, Alana A
Kitko, Carrie
Kurtzberg, Joanne
Lehmann, Leslie
O'Brien, Tracey
Pulsipher, Michael A
Smith, Franklin O
Zhang, Mei-Jie
Eapen, Mary
Carpenter, Paul A
CIBMTR Pediatric Cancer Working Committee
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Abstract
We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free survival (DFS) was 24% at a median of 3 years. Post-transplant leukemic relapse was more frequent than expected for children with DS-ALL (54%) than for non-DS ALL. These data suggest leukemic relapse rather than transplant toxicity is the most important cause of treatment failure. Advancements in leukemia control are especially needed for improvement in HCT outcomes for DS-ALL.
Type
Journal article
Subject
CIBMTR Pediatric Cancer Working Committee
Humans
Down Syndrome
Graft vs Host Disease
Genetic Predisposition to Disease
Recurrence
Tacrolimus
Cyclosporine
Antineoplastic Combined Chemotherapy Protocols
Immunosuppressive Agents
Myeloablative Agonists
Disease-Free Survival
Treatment Outcome
Transplantation Conditioning
Combined Modality Therapy
Salvage Therapy
Whole-Body Irradiation
Remission Induction
Bone Marrow Transplantation
Hematopoietic Stem Cell Transplantation
Registries
Retrospective Studies
Adolescent
Adult
Child
Child, Preschool
Infant
Living Donors
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Kaplan-Meier Estimate
Allografts
Permalink
https://hdl.handle.net/10161/24654
Published Version (Please cite this version)
10.1002/pbc.24918
Publication Info
Hitzler, Johann K; He, Wensheng; Doyle, John; Cairo, Mitchell; Camitta, Bruce M; Chan, Ka Wah; ... CIBMTR Pediatric Cancer Working Committee (2014). Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. Pediatric blood & cancer, 61(6). pp. 1126-1128. 10.1002/pbc.24918. Retrieved from https://hdl.handle.net/10161/24654.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Kurtzberg

Joanne Kurtzberg

Jerome S. Harris Distinguished Professor of Pediatrics
Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology, pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation, and novel applications of cord blood and birthing tissues in the emerging fields of cellular therapies and regenerative medicine.   Dr. Kurtzberg serves as the Director of the Marcus Center for Cellular Cures (MC3), Director of the Pediatric Transplant and Cellular Therapy Program, Director of the Carolina
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