Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.
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Depressed mood in pregnancy has been linked to low birth weight (LBW, 4,500 g) infants had 5.9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed mood in pregnancy is associated with LBW, and that MEG3 and IGF2 plasticity may play important roles.
Insulin-Like Growth Factor II
Cell Cycle Proteins
Tumor Suppressor Proteins
Sequence Analysis, DNA
High-Throughput Nucleotide Sequencing
RNA, Long Noncoding
Published Version (Please cite this version)10.4161/epi.20734
Publication InfoLiu, Y; Murphy, SK; Murtha, AP; Fuemmeler, BF; Schildkraut, J; Huang, Z; ... Hoyo, C (2012). Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics : official journal of the DNA Methylation Society, 7(7). pp. 735-746. 10.4161/epi.20734. Retrieved from https://hdl.handle.net/10161/24661.
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Bernard Frank Fuemmeler
Adjunct Associate Professor in the Department of Community and Family Medicine
Unhealthy lifestyle factors, such as tobacco use, poor dietary intake, lack of physical activity, and high body mass index are the leading causes of cancer and chronic disease. The prevention of such diseases will be advanced through a more thorough understanding of the complex determinants of these lifestyle factors and the development of novel interventions that help change individual behavior for the better. Dr. Fuemmeler’s program of research takes a lifespan approach toward understand
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Assistant Professor in Obstetrics and Gynecology
Dr. Huang is an Assistant Professor in the Department of Obstetrics and Gynecology, Division of Reproductive Sciences, at Duke University Medical Center. She obtained her MD at North China Coal Medical University in China and her PhD at the University of Heidelberg in Germany under the mentorship of Dr. Ralph Witzgall. She did her postdoctoral training with Dr. Jiemin Wong at Baylor College of Medicine, studying how histone methylation and chromatin modifications regulate androgen receptor tr
Edwin Severin Iversen Jr.
Research Professor of Statistical Science
Bayesian statistical modeling with application to problems in genetic epidemiology and cancer research; models for epidemiological risk assessment, including hierarchical methods for combining related epidemiological studies; ascertainment corrections for high risk family data; analysis of high-throughput genomic data sets.
Jerome S. Harris Distinguished Professor of Pediatrics
Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology, pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation, and novel applications of cord blood and birthing tissues in the emerging fields of cellular therapies and regenerative medicine. Dr. Kurtzberg serves as the Director of the Marcus Center for Cellular Cures (MC3), Director of the Pediatric Transplant and Cellular Therapy Program, Director of the Carolina
Susan Kay Murphy
Associate Professor in Obstetrics and Gynecology
My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease. I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the ide
Amy Patricia Murtha
Professor of Obstetrics and Gynecology
Dr. Amy Murtha is a Professor in the Department of Obstetrics and Gynecology and Department of Pediatrics, and past Vice Chair for Research in Obstetrics and Gynecology. After graduating from the Medical College of Pennsylvania in 1992 she completed her residency in OB-GYN and fellowship in Maternal Fetal Medicine (MFM) at Duke University then joined the faculty at Duke in 1998. Dr. Murtha served as interim Chair for the Department of OB-GYN and Fellowship Director for the mater
Joellen Martha Schildkraut
Professor Emeritus in Family Medicine and Community Health
Dr. Schildkraut is an epidemiologist whose research includes the molecular epidemiology of ovarian, breast and brain cancers. Dr. Schildkraut's research interests include the study of the interaction between genetic and environmental factors. She is currently involved in a large study of genome wide association and ovarian cancer risk and survival. Some of her work is also focused on particular genetic pathways including the DNA repair and apoptosis pathways. She currently leads a study of
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