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Novel oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation after transcatheter aortic valve replacement: A systematic review and meta-analysis.

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Date
2022-04-27
Authors
Memon, Muhammad Mustafa
Siddiqui, Asad Ali
Amin, Emaan
Shaikh, Fahd Niaz
Khan, Muhammad Shahzeb
Doukky, Rami
Krasuski, Richard A
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Abstract
<h4>Background</h4>The efficacy and safety of novel oral anticoagulants (NOACs) compared to the current guideline-recommended vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients undergoing transcatheter aortic valve replacement (TAVR) has not been well established. We pooled evidence from all available studies to assess the risks and benefits of this drug class.<h4>Methods</h4>We queried electronic databases (MEDLINE, Scopus, and Cochrane central) up until January 28th, 2022 for studies comparing NOACs to VKAs in AF patients undergoing TAVR. Results from studies were presented as risk ratios (RR) and pooled using a random-effects model. Subgroup analysis by study design and meta-regression analysis were performed to explore heterogeneity.<h4>Results</h4>A total of 12 studies (3 RCTs and 9 observational) containing 12,203 patients (mean age 81.2 years; 50.5% men) were identified and included in the analysis. Pooled analysis revealed no significant difference between NOACs and VKAs in terms of stroke or systemic embolism (RR: 0.78; p = 0.18), major bleeding (RR: 0.84; p = 0.32), intracranial hemorrhage (RR 0.61; p = 0.06), all-cause mortality (RR: 0.69; p = 0.07), and myocardial infarction (RR: 1.60; p = 0.24) at a mean length of follow-up of 15.1 months. RCTs and observational studies did not significantly differ across outcomes on subgroup analysis. Meta-regression analysis found heterogeneity in all-cause mortality to be significantly explained by percentage of males (coefficient: 0.049, p = 0.007), mean age (coefficient: 0.221, p < 0.001), and CHA2DS2-VASc score (coefficient: -1.657, p < 0.001).<h4>Conclusions</h4>This meta-analysis suggests that outcomes with NOACs do not significantly differ compared to VKAs following TAVR in patients with AF.
Type
Journal article
Subject
Warfarin
atrial fibrillation
novel oral anticoagulants
transcatheter aortic valve replacement
vitamin K antagonists
Permalink
https://hdl.handle.net/10161/24976
Published Version (Please cite this version)
10.1002/ccd.30213
Publication Info
Memon, Muhammad Mustafa; Siddiqui, Asad Ali; Amin, Emaan; Shaikh, Fahd Niaz; Khan, Muhammad Shahzeb; Doukky, Rami; & Krasuski, Richard A (2022). Novel oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation after transcatheter aortic valve replacement: A systematic review and meta-analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 10.1002/ccd.30213. Retrieved from https://hdl.handle.net/10161/24976.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Krasuski

Richard Andrew Krasuski

Professor of Medicine
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