Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection.
Date
2010
Author
Advisors
Samei, Ehsan
Lo, Joseph
Yoo, Sua
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Abstract
PURPOSE: Mammography is known to be one of the most difficult radiographic exams to
interpret. Mammography has important limitations, including the superposition of normal
tissue that can obscure a mass, chance alignment of normal tissue to mimic a true
lesion and the inability to derive volumetric information. It has been shown that
stereomammography can overcome these deficiencies by showing that layers of normal
tissue lay at different depths. If standard stereomammography (i.e., a single stereoscopic
pair consisting of two projection images) can significantly improve lesion detection,
how will multiview stereoscopy (MVS), where many projection images are used, compare
to mammography? The aim of this study was to assess the relative performance of MVS
compared to mammography for breast mass detection. METHODS: The MVS image sets consisted
of the 25 raw projection images acquired over an arc of approximately 45 degrees using
a Siemens prototype breast tomosynthesis system. The mammograms were acquired using
a commercial Siemens FFDM system. The raw data were taken from both of these systems
for 27 cases and realistic simulated mass lesions were added to duplicates of the
27 images at the same local contrast. The images with lesions (27 mammography and
27 MVS) and the images without lesions (27 mammography and 27 MVS) were then postprocessed
to provide comparable and representative image appearance across the two modalities.
All 108 image sets were shown to five full-time breast imaging radiologists in random
order on a state-of-the-art stereoscopic display. The observers were asked to give
a confidence rating for each image (0 for lesion definitely not present, 100 for lesion
definitely present). The ratings were then compiled and processed using ROC and variance
analysis. RESULTS: The mean AUC for the five observers was 0.614 +/- 0.055 for mammography
and 0.778 +/- 0.052 for multiview stereoscopy. The difference of 0.164 +/- 0.065 was
statistically significant with a p-value of 0.0148. CONCLUSIONS: The differences in
the AUCs and the p-value suggest that multiview stereoscopy has a statistically significant
advantage over mammography in the detection of simulated breast masses. This highlights
the dominance of anatomical noise compared to quantum noise for breast mass detection.
It also shows that significant lesion detection can be achieved with MVS without any
of the artifacts associated with tomosynthesis.
Type
Master's thesisDepartment
Medical PhysicsSubject
AlgorithmsBreast Neoplasms
Computer Graphics
Humans
Image Processing, Computer-Assisted
Mammography
ROC Curve
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https://hdl.handle.net/10161/2508Citation
Webb, Lincoln Jon (2010). Comparative performance of multiview stereoscopic and mammographic display modalities
for breast lesion detection. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/2508.Collections
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