Show simple item record

Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols.

dc.contributor.author Sharma, Shobhit
dc.contributor.author Kapadia, Anuj
dc.contributor.author Ria, Francesco
dc.contributor.author Segars, W Paul
dc.contributor.author Samei, Ehsan
dc.date.accessioned 2022-06-15T16:48:09Z
dc.date.available 2022-06-15T16:48:09Z
dc.date.issued 2022-06-11
dc.identifier.issn 0094-2405
dc.identifier.issn 2473-4209
dc.identifier.uri https://hdl.handle.net/10161/25118
dc.description.abstract <h4>Purpose</h4>The gold-standard method for estimation of patient-specific organ doses in digital tomosynthesis (DT) requires protocol-specific Monte Carlo (MC) simulations of radiation transport in anatomically accurate computational phantoms. Although accurate, MC simulations are computationally expensive, leading to a turnaround time in the order of core hours for simulating a single exam. This limits their clinical utility. The purpose of this study is to overcome this limitation by utilizing patient- and protocol-specific MC simulations to develop a comprehensive database of air-kerma-normalized organ dose coefficients for a virtual population of adult and pediatric patient models over an expanded set of exam protocols in DT for retrospective and prospective estimation of radiation dose in clinical tomosynthesis.<h4>Materials and methods</h4>A clinically representative virtual population of 14 patient models was used, with pediatric models (M and F) at ages 1, 5, 10, and 15 and adult patient models (M and F) with BMIs at 10<sup>th</sup> , 50<sup>th</sup> , and 90<sup>th</sup> percentiles of the US population. A GPU-based MC simulation framework was used to simulate organ doses in the patient models, incorporating the scanner-specific configuration of a clinical DT system (VolumeRad, GE Healthcare, Waukesha, WI) and an expanded set of exam protocols including 21 distinct acquisition techniques for imaging a variety of anatomical regions (head and neck, thorax, spine, abdomen, and knee). Organ dose coefficients (h<sub>n</sub> ) were estimated by normalizing organ dose estimates to air kerma at 70 cm (X<sub>70cm</sub> ) from the source in the scout view. The corresponding coefficients for projection radiography were approximated using organ doses estimated for the scout view. The organ dose coefficients were further used to compute air-kerma-normalized patient-specific effective dose coefficients (K<sub>n</sub> ) for all combinations of patients and protocols, and a comparative analysis examining the variation of radiation burden across sex, age, and exam protocols in DT, and with projection radiography was performed.<h4>Results</h4>The database of organ dose coefficients (h<sub>n</sub> ) containing 294 distinct combinations of patients and exam protocols was developed and made publicly available. The values of K<sub>n</sub> were observed to produce estimates of effective dose in agreement with prior studies and consistent with magnitudes expected for pediatric and adult patients across the different exam protocols, with head and neck regions exhibiting relatively lower and thorax and C-spine (apsc, apcs) regions relatively higher magnitudes. The ratios (r = K<sub>n</sub> /K<sub>n,rad</sub> ) quantifying the differences air-kerma-normalized patient-specific effective doses between DT and projection radiography were centered around 1.0 for all exam protocols, with the exception of protocols covering the knee region (pawk, patk).<h4>Conclusions</h4>This study developed a database of organ dose coefficients for a virtual population of 14 adult and pediatric XCAT patient models over a set of 21 exam protocols in DT. Using empirical measurements of air kerma in the clinic, these organ dose coefficients enable practical retrospective and prospective patient-specific radiation dosimetry. The computation of air-kerma-normalized patient-specific effective doses further enable the comparison of radiation burden to the patient populations between protocols and between imaging modalities (e.g., DT and projection radiography), as presented in this study. This article is protected by copyright. All rights reserved.
dc.language eng
dc.publisher Wiley
dc.relation.ispartof Medical physics
dc.relation.isversionof 10.1002/mp.15798
dc.subject Task Group 321
dc.subject XCAT
dc.subject monte carlo
dc.subject patient specific
dc.subject radiation dosimetry & risk
dc.subject tomosynthesis
dc.title Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols.
dc.type Journal article
duke.contributor.id Kapadia, Anuj|0295298
duke.contributor.id Ria, Francesco|0691782
duke.contributor.id Segars, W Paul|0287434
dc.date.updated 2022-06-15T16:48:08Z
pubs.organisational-group Duke
pubs.organisational-group School of Medicine
pubs.organisational-group Staff
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Radiology
pubs.publication-status Published
duke.contributor.orcid Ria, Francesco|0000-0001-5902-7396


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record