Skip to main content
Duke University Libraries
DukeSpace Scholarship by Duke Authors
  • Login
  • Ask
  • Menu
  • Login
  • Ask a Librarian
  • Search & Find
  • Using the Library
  • Research Support
  • Course Support
  • Libraries
  • About
View Item 
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cortical stimulation mapping for localization of visual and auditory language in pediatric epilepsy patients.

Thumbnail
View / Download
11.2 Mb
Date
2019-11-08
Authors
Muh, Carrie R
Chou, Naomi D
Rahimpour, Shervin
Komisarow, Jordan M
Spears, Tracy G
Fuchs, Herbert E
Serafini, Sandra
Grant, Gerald A
Show More
(8 total)
Repository Usage Stats
0
views
0
downloads
Abstract
OBJECTIVE:To determine resection margins near eloquent tissue, electrical cortical stimulation (ECS) mapping is often used with visual naming tasks. In recent years, auditory naming tasks have been found to provide a more comprehensive map. Differences in modality-specific language sites have been found in adult patients, but there is a paucity of research on ECS language studies in pediatric patients. The goals of this study were to evaluate word-finding distinctions between visual and auditory modalities and identify which cortical subregions most often contain critical language function in a pediatric population. METHODS:Twenty-one pediatric patients with epilepsy or temporal lobe pathology underwent ECS mapping using visual (n = 21) and auditory (n = 14) tasks. Fisher's exact test was used to determine whether the frequency of errors in the stimulated trials was greater than the patient's baseline error rate for each tested modality and subregion. RESULTS:While the medial superior temporal gyrus was a common language site for both visual and auditory language (43.8% and 46.2% of patients, respectively), other subregions showed significant differences between modalities, and there was significant variability between patients. Visual language was more likely to be located in the anterior temporal lobe than was auditory language. The pediatric patients exhibited fewer parietal language sites and a larger range of sites overall than did adult patients in previously published studies. CONCLUSIONS:There was no single area critical for language in more than 50% of patients tested in either modality for which more than 1 patient was tested (n > 1), affirming that language function is plastic in the setting of dominant-hemisphere pathology. The high rates of language function throughout the left frontal, temporal, and anterior parietal regions with few areas of overlap between modalities suggest that ECS mapping with both visual and auditory testing is necessary to obtain a comprehensive language map prior to epileptic focus or tumor resection.
Type
Journal article
Subject
AMTG = anterior middle temporal gyrus
ASMG = anterior supramarginal gyrus
ASTG = anterior superior temporal gyrus
ECS = electrical cortical stimulation
MITG = medial inferior temporal gyrus
MMTG = medial middle temporal gyrus
MPrG = medial precentral gyrus
MSTG = medial superior temporal gyrus
OpIFG = opercular inferior frontal gyrus
PMFG = posterior middle frontal gyrus
PMTG = posterior middle temporal gyrus
PSMG = posterior supramarginal gyrus
PSTG = posterior superior temporal gyrus
PolMTG = polar middle temporal gyrus
auditory
brain mapping
cortical stimulation
epilepsy
fMRI = functional MRI
language
pediatric
temporal
visual
Permalink
https://hdl.handle.net/10161/25391
Published Version (Please cite this version)
10.3171/2019.8.peds1922
Publication Info
Muh, Carrie R; Chou, Naomi D; Rahimpour, Shervin; Komisarow, Jordan M; Spears, Tracy G; Fuchs, Herbert E; ... Grant, Gerald A (2019). Cortical stimulation mapping for localization of visual and auditory language in pediatric epilepsy patients. Journal of neurosurgery. Pediatrics, 25(2). pp. 1-10. 10.3171/2019.8.peds1922. Retrieved from https://hdl.handle.net/10161/25391.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
  • Scholarly Articles
More Info
Show full item record

Scholars@Duke

Fuchs

Herbert Edgar Fuchs

Professor of Neurosurgery
Clinical neuro-oncology research including collaborations studying molecular genetics of childhood brain tumors. Potential role of the free electron laser in surgery of pediatric brain tumors. Current work includes animal models with human brain tumor xenografts in preclinical studies. Collaboration with the neurooncology laboratory of Dr. Darell Bigner in preclinical studies of new therapeutic agents.
Grant

Gerald Arthur Grant

Professor of Neurosurgery
Komisarow

Jordan Komisarow

Assistant Professor of Neurosurgery
Muh

Carrie Rebecca Muh

Adjunct Assistant Professor in the Department of Neurosurgery
Carrie R. Muh is a Pediatric Neurosurgeon specializing in the surgical treatment of epilepsy. She worked full time at Duke University from 2011 to 2019 and became Adjunct faculty when she moved to New York Medical College in 2019. Dr. Muh grew up in California and began scientific research in high school as part of the NASA Student Space Biology initiative. She went on to study at the Massachusetts Institute of Technology (MIT) where she earned two Bachelor's degrees, in Biology
Alphabetical list of authors with Scholars@Duke profiles.
Open Access

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

Rights for Collection: Scholarly Articles


Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info

Related items

Showing items related by title, author, creator, and subject.

  • Thumbnail

    Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees. 

    Bauernfeind, Amy L; Soderblom, Erik J; Turner, Meredith E; Moseley, M Arthur; Ely, John J; Hof, Patrick R; Sherwood, Chet C; ... (9 authors) (Genome Biol Evol, 2015-07-10)
    Although transcriptomic profiling has become the standard approach for exploring molecular differences in the primate brain, very little is known about how the expression levels of gene transcripts relate to downstream protein ...
  • Thumbnail

    The temporal distribution of autobiographical memory: changes in reliving and vividness over the life span do not explain the reminiscence bump. 

    Janssen, Steve MJ; Rubin, David C; St Jacques, Peggy L (Mem Cognit, 2011-01)
    When autobiographical memories are elicited with word cues, personal events from middle childhood to early adulthood are overrepresented compared to events from other periods. It is, however, unclear whether these memories ...
  • Thumbnail

    The reminiscence bump in the temporal distribution of the best football players of all time: Pelé, Cruijff or Maradona? 

    Janssen, Steve MJ; Rubin, David C; Conway, Martin A (Q J Exp Psychol (Hove), 2012)
    The reminiscence bump is the tendency to recall more autobiographical memories from adolescence and early adulthood than from adjacent lifetime periods. In this online study, the robustness of the reminiscence bump was examined ...

Make Your Work Available Here

How to Deposit

Browse

All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

My Account

LoginRegister

Statistics

View Usage Statistics
Duke University Libraries

Contact Us

411 Chapel Drive
Durham, NC 27708
(919) 660-5870
Perkins Library Service Desk

Digital Repositories at Duke

  • Report a problem with the repositories
  • About digital repositories at Duke
  • Accessibility Policy
  • Deaccession and DMCA Takedown Policy

TwitterFacebookYouTubeFlickrInstagramBlogs

Sign Up for Our Newsletter
  • Re-use & Attribution / Privacy
  • Harmful Language Statement
  • Support the Libraries
Duke University