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Age-related changes in the upper respiratory microbiome are associated with SARS-CoV-2 susceptibility and illness severity.
Abstract
Children are less susceptible to SARS-CoV-2 and typically have milder illness courses
than adults. We studied the nasopharyngeal microbiomes of 274 children, adolescents,
and young adults with SARS-CoV-2 exposure using 16S rRNA gene sequencing. We find
that higher abundances of Corynebacterium species are associated with SARS-CoV-2 infection
and SARS-CoV-2-associated respiratory symptoms, while higher abundances of Dolosigranulum
pigrum are present in SARS-CoV-2-infected individuals without respiratory symptoms.
We also demonstrate that the abundances of these bacteria are strongly, and independently,
associated with age, suggesting that the nasopharyngeal microbiome may be a potentially
modifiable mechanism by which age influences SARS-CoV-2 susceptibility and severity.
SUMMARY: Evaluation of nasopharyngeal microbiome profiles in children, adolescents,
and young adults with a SARS-CoV-2-infected close contact identified specific bacterial
species that vary in abundance with age and are associated with SARS-CoV-2 susceptibility
and the presence of SARS-CoV-2-associated respiratory symptoms.
Type
Journal articlePermalink
https://hdl.handle.net/10161/25651Published Version (Please cite this version)
10.1101/2021.03.20.21252680Publication Info
(2021). Age-related changes in the upper respiratory microbiome are associated with SARS-CoV-2
susceptibility and illness severity. medRxiv. 10.1101/2021.03.20.21252680. Retrieved from https://hdl.handle.net/10161/25651.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Thomas Norton Denny
Professor in Medicine
Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine
Institute (DHVI), Associate Dean for Duke Research and Discovery @RTP, and a Professor
of Medicine in the Department of Medicine at Duke University Medical Center. He is
also an Affiliate Member of the Duke Global Health Institute. Previously, he served
on the Health Sector Advisory Council of the Duke University Fuquay School of Business.
Prior to joining Duke, he was an Associate Professor of Pathology, Labo
Sarah Mabrey Heston
Assistant Professor of Pediatrics
I am a Pediatric Transplant Infectious Diseases physician-scientist. Clinically, I
diagnose and treat infections in immunocompromised children who have either undergone
transplantation or who are receiving chemotherapy. My research interests are in utilizing
the microbiome to improve clinical outcomes following transplantation. Specifically,
I am evaluating the gut microbiomes of children undergoing hematopoietic cell transplantation
(HCT) to identify actionable interventions to reduce mucosal b
Matthew Kelly
Associate Professor of Pediatrics
My research is broadly focused on elucidating the complex interactions that exist
between the host microbiome and exogenous pathogens that cause infections in children.
We have several ongoing projects evaluating: 1) the impact of the upper respiratory
microbiome on the risk of colonization and invasion by bacterial respiratory pathogens
among infants in Botswana; 2) associations between the gut microbiome of pediatric
stem cell transplant recipients and the risk of infections (bloodstream infec
Michael Anthony Moody
Professor of Pediatrics
Tony Moody, MD is a Professor in the Department of Pediatrics, Division of Infectious
Diseases and Professor in the Department of Integrative Immunobiology at Duke University
Medical Center. Research in the Moody lab is focused on understanding the B cell responses
during infection, vaccination, and disease. The lab has become a resource for human
phenotyping, flow characterization, staining and analysis at the Duke Human Vaccine
Institute (DHVI). The Moody lab is currently funded to study in
John Franklin Rawls
James B. Duke Distinguished Professor
We seek to understand how the intestinal microbiome contributes to vertebrate physiology
and disease. To that end, we leverage complementary zebrafish and mouse models to
study the integrative physiology of host-microbiome interactions. This work has identified
novel and conserved mechanisms by which intestinal bacteria regulate dietary fat metabolism
and systemic innate immunity. We also apply genomic approaches in these animal models
to understand the transcriptional regulatory pathways utiliz
Alexandre Tellechea Rotta
Professor of Pediatrics
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