The Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study: design, methods, and baseline characteristics.
Abstract
<h4>Objectives</h4>Coronavirus Disease 2019 (COVID-19) is a viral illness with public
health importance. The Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study
is a prospective, longitudinal cohort study designed to contribute valuable information
on community prevalence of active COVID-19 infection and SARS-CoV-2 antibodies as
the pandemic and responses to it have and continue to evolve. We present the rationale,
study design, and baseline characteristics of the C3PI Study.<h4>Methods</h4>We recruited
1,426 participants between June 2020 and August 2020 from the Measurement to Understand
the Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) Study Community Registry
and Biorepository, a previously established, community-based, longitudinal cohort.
Participants completed a baseline survey and follow-up surveys every two weeks. A
nested weighted, random sub-cohort (n=300) was recruited to measure the incidence
and prevalence of active COVID-19 infection and SARS-CoV-2 IgG antibodies.<h4>Results</h4>The
sub-cohort was younger (56 vs 61 years), had more men (39.0% vs 30.9%), and a higher
proportion of Hispanic (11.0% vs 5.1%) and Black participants (17.0% vs 8.2%) compared
with the overall cohort. They had similar anthropometrics and medical histories, but
a greater proportion of the sub-cohort had a higher educational degree (36.1% vs 31.3%)
and reported a pre-pandemic annual household income of >$90,000 (57.1% vs 47.9%).<h4>Conclusion</h4>This
study is part of a multisite consortium that will provide critical data on the epidemiology
of COVID-19 and community perspectives about the pandemic, behaviors and mitigation
strategies, and individual and community burden in North Carolina.
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Show full item recordScholars@Duke
Thomas Norton Denny
Professor in Medicine
Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine
Institute (DHVI), Associate Dean for Duke Research and Discovery @RTP, and a Professor
of Medicine in the Department of Medicine at Duke University Medical Center. He is
also an Affiliate Member of the Duke Global Health Institute. Previously, he served
on the Health Sector Advisory Council of the Duke University Fuquay School of Business.
Prior to joining Duke, he was an Associate Professor of Pathology, Labo
Coralei Neighbors
Student
Coralei Neighbors is a Ph.D. Student at the Department of Population Health Sciences
in the Duke School of Medicine. She received her Bachelor of Science in Education
for Health Science Studies from Baylor University and her Master of Science in Global
Health from Duke University. Coralei has experience in national and international
infectious disease research, with interests in infectious disease surveillance, health
economics, and global health policy.
Laura Kristin Newby
Professor of Medicine
Research Description General Focus: Clinical investigation the process and treatment
of acute and chronic coronary artery disease and systems issues for delivery of care
to patients with these illnesses. Particular interests include management of patients
with chest pain and unstable angina, evaluation of the use of biochemical markers
other than CK-MB for diagnosis and risk stratification in these patients, issues related
to coronary artery disease in women, and systems issues rega
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