ALERT: This system is being upgraded on Tuesday December 12. It will not be available
for use for several hours that day while the upgrade is in progress. Deposits to DukeSpace
will be disabled on Monday December 11, so no new items are to be added to the repository
while the upgrade is in progress. Everything should be back to normal by the end of
day, December 12.
Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours.
Abstract
Locally advanced pancreatic tumours are highly resistant to conventional radiochemotherapy.
Here we show that such resistance can be surmounted by an injectable depot of thermally
responsive elastin-like polypeptide (ELP) conjugated with iodine-131 radionuclides
(131I-ELP) when combined with systemically delivered nanoparticle albumin-bound paclitaxel.
This combination therapy induced complete tumour regressions in diverse subcutaneous
and orthotopic mouse models of locoregional pancreatic tumours. 131I-ELP brachytherapy was effective independently of the paclitaxel formulation and
dose, but external beam radiotherapy (EBRT) only achieved tumour-growth inhibition
when co-administered with nanoparticle paclitaxel. Histological analyses revealed
that 131I-ELP brachytherapy led to changes in the expression of intercellular collagen and
junctional proteins within the tumour microenvironment. These changes, which differed
from those of EBRT-treated tumours, correlated with the improved delivery and accumulation
of paclitaxel nanoparticles within the tumour. Our findings support the further translational
development of 131I-ELP depots for the synergistic treatment of localized pancreatic cancer.
Type
Journal articleSubject
AnimalsMice
Pancreatic Neoplasms
Iodine Radioisotopes
Paclitaxel
Biopolymers
Elastin
Peptides
Brachytherapy
Nanoparticles
Tumor Microenvironment
Albumin-Bound Paclitaxel
Permalink
https://hdl.handle.net/10161/26126Published Version (Please cite this version)
10.1038/s41551-022-00949-4Publication Info
(2022). Brachytherapy via a depot of biopolymer-bound 131I synergizes with nanoparticle paclitaxel in therapy-resistant pancreatic tumours.
Nature biomedical engineering, 6(10). pp. 1148-1166. 10.1038/s41551-022-00949-4. Retrieved from https://hdl.handle.net/10161/26126.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Ashutosh Chilkoti
Alan L. Kaganov Distinguished Professor of Biomedical Engineering
Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair
of the Department of Biomedical Engineering at Duke University.
My research in biomolecular engineering and biointerface science focuses on the development
of new molecular tools and technologies that borrow from molecular biology, protein
engineering, polymer chemistry and surface science that we then exploit for the development
of applications that span the range from bioseparations, plasmonic bio
David Guy Kirsch
Barbara Levine University Distinguished Professor
My clinical interests are the multi-modality care of patients with bone and soft tissue
sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing
mouse models of cancer to study cancer and radiation biology in order to develop new
cancer therapies in the pre-clinical setting.
Soumen Saha
Research Scientist
Kyle C. Strickland
Adjunct Associate Professor of Pathology
Dr. Strickland specializes in cytopathology and women's and perinatal surgical pathology.
His areas of interest include epithelial and mesenchymal gynecologic neoplasia and
fine needle aspiration cytology.
Michael Rod Zalutsky
Jonathan Spicehandler, M.D. Distinguished Professor of Neuro Oncology, in the School
of Medicine
The overall objective of our laboratory is the development of novel radioactive compounds
for improving the diagnosis and treatment of cancer. This work primarily involves
radiohalo-genation of biomolecules via site-specific approaches, generally via demetallation
reactions. Radionuclides utilized for imaging include I-123, I-124 and F-18, the later
two being of particular interest because they can be used for the quantification of
biochemical and physiological processes in the living huma
Alphabetical list of authors with Scholars@Duke profiles.
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info