Lung Transplantation and the Era of the Sensitized Patient.
Abstract
Long term outcomes in lung transplant are limited by the development of chronic lung
allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection
(AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies
in lung transplant candidates, "sensitized patients" may predispose patients to AMR,
CLAD, and higher mortality after transplant. This review will discuss issues surrounding
the sensitized patient, including mechanisms of sensitization, implications within
lung transplant, and management strategies.
Type
Journal articleSubject
HumansImmunosuppressive Agents
Isoantibodies
HLA Antigens
Histocompatibility Testing
Treatment Outcome
Lung Transplantation
Risk Assessment
Risk Factors
Transplantation Tolerance
Histocompatibility
Graft Rejection
Graft Survival
Time Factors
Permalink
https://hdl.handle.net/10161/26148Published Version (Please cite this version)
10.3389/fimmu.2021.689420Publication Info
Young, Katherine A; Ali, Hakim A; Beermann, Kristi J; Reynolds, John M; & Snyder,
Laurie D (2021). Lung Transplantation and the Era of the Sensitized Patient. Frontiers in immunology, 12. pp. 689420. 10.3389/fimmu.2021.689420. Retrieved from https://hdl.handle.net/10161/26148.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Hakim Azfar Ali
Associate Professor of Medicine
John Michael Reynolds
Professor of Medicine
Laurie D. Snyder
Professor of Medicine
Advanced lung disease, lung transplantation, interstitial lung disease, immune monitoring
Katherine Young
Assistant Professor of Medicine
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info