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Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021.

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Date
2022-08
Authors
Coates, Laura C
Soriano, Enrique R
Corp, Nadia
Bertheussen, Heidi
Callis Duffin, Kristina
Campanholo, Cristiano B
Chau, Jeffrey
Eder, Lihi
Fernández-Ávila, Daniel G
FitzGerald, Oliver
Garg, Amit
Gladman, Dafna D
Goel, Niti
Helliwell, Philip S
Husni, M Elaine
Jadon, Deepak R
Katz, Arnon
Laheru, Dhruvkumar
Latella, John
Leung, Ying-Ying
Lindsay, Christine
Lubrano, Ennio
Mazzuoccolo, Luis Daniel
Mease, Philip J
O'Sullivan, Denis
Ogdie, Alexis
Olsder, Wendy
Palominos, Penelope Esther
Schick, Lori
Steinkoenig, Ingrid
de Wit, Maarten
van der Windt, DA
Kavanaugh, Arthur
GRAPPA Treatment Recommendations domain subcommittees
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Abstract
Since the second version of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations were published in 2015, therapeutic options for psoriatic arthritis (PsA) have advanced considerably. This work reviews the literature since the previous recommendations (data published 2013-2020, including conference presentations between 2017 and 2020) and reports high-quality, evidence-based, domain-focused recommendations for medication selection in PsA developed by GRAPPA clinicians and patient research partners. The overarching principles for the management of adults with PsA were updated by consensus. Principles considering biosimilars and tapering of therapy were added, and the research agenda was revised. Literature searches covered treatments for the key domains of PsA: peripheral arthritis, axial disease, enthesitis, dactylitis, and skin and nail psoriasis; additional searches were performed for PsA-related conditions (uveitis and inflammatory bowel disease) and comorbidities. Individual subcommittees used a GRADE-informed approach, taking into account the quality of evidence for therapies, to generate recommendations for each of these domains, which were incorporated into an overall schema. Choice of therapy for an individual should ideally address all disease domains active in that patient, supporting shared decision-making. As safety issues often affect potential therapeutic choices, additional consideration was given to relevant comorbidities. These GRAPPA treatment recommendations provide up-to-date, evidence-based guidance on PsA management for clinicians and people with PsA.
Type
Journal article
Subject
GRAPPA Treatment Recommendations domain subcommittees
Humans
Arthritis, Psoriatic
Psoriasis
Consensus
Comorbidity
Adult
Biosimilar Pharmaceuticals
Permalink
https://hdl.handle.net/10161/26279
Published Version (Please cite this version)
10.1038/s41584-022-00798-0
Publication Info
Coates, Laura C; Soriano, Enrique R; Corp, Nadia; Bertheussen, Heidi; Callis Duffin, Kristina; Campanholo, Cristiano B; ... GRAPPA Treatment Recommendations domain subcommittees (2022). Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021. Nature reviews. Rheumatology, 18(8). pp. 465-479. 10.1038/s41584-022-00798-0. Retrieved from https://hdl.handle.net/10161/26279.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Niti Goel

Adjunct Assistant Professor in the Department of Medicine
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