Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021.
Abstract
Since the second version of the Group for Research and Assessment of Psoriasis and
Psoriatic Arthritis (GRAPPA) treatment recommendations were published in 2015, therapeutic
options for psoriatic arthritis (PsA) have advanced considerably. This work reviews
the literature since the previous recommendations (data published 2013-2020, including
conference presentations between 2017 and 2020) and reports high-quality, evidence-based,
domain-focused recommendations for medication selection in PsA developed by GRAPPA
clinicians and patient research partners. The overarching principles for the management
of adults with PsA were updated by consensus. Principles considering biosimilars and
tapering of therapy were added, and the research agenda was revised. Literature searches
covered treatments for the key domains of PsA: peripheral arthritis, axial disease,
enthesitis, dactylitis, and skin and nail psoriasis; additional searches were performed
for PsA-related conditions (uveitis and inflammatory bowel disease) and comorbidities.
Individual subcommittees used a GRADE-informed approach, taking into account the quality
of evidence for therapies, to generate recommendations for each of these domains,
which were incorporated into an overall schema. Choice of therapy for an individual
should ideally address all disease domains active in that patient, supporting shared
decision-making. As safety issues often affect potential therapeutic choices, additional
consideration was given to relevant comorbidities. These GRAPPA treatment recommendations
provide up-to-date, evidence-based guidance on PsA management for clinicians and people
with PsA.
Type
Journal articleSubject
GRAPPA Treatment Recommendations domain subcommitteesHumans
Arthritis, Psoriatic
Psoriasis
Consensus
Comorbidity
Adult
Biosimilar Pharmaceuticals
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https://hdl.handle.net/10161/26279Published Version (Please cite this version)
10.1038/s41584-022-00798-0Publication Info
Coates, Laura C; Soriano, Enrique R; Corp, Nadia; Bertheussen, Heidi; Callis Duffin,
Kristina; Campanholo, Cristiano B; ... GRAPPA Treatment Recommendations domain subcommittees (2022). Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated
treatment recommendations for psoriatic arthritis 2021. Nature reviews. Rheumatology, 18(8). pp. 465-479. 10.1038/s41584-022-00798-0. Retrieved from https://hdl.handle.net/10161/26279.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Niti Goel
Adjunct Assistant Professor in the Department of Medicine

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