Isolation and characterization of mesenchymal stem cells in orthopaedics and the emergence of compact bone mesenchymal stem cells as a promising surgical adjunct.
Abstract
The potential clinical and economic impact of mesenchymal stem cell (MSC) therapy
is immense. MSCs act through multiple pathways: (1) as "trophic" cells, secreting
various factors that are immunomodulatory, anti-inflammatory, anti-apoptotic, proangiogenic,
proliferative, and chemoattractive; (2) in conjunction with cells native to the tissue
they reside in to enhance differentiation of surrounding cells to facilitate tissue
regrowth. Researchers have developed methods for the extraction and expansion of MSCs
from animal and human tissues. While many sources of MSCs exist, including adipose
tissue and iliac crest bone graft, compact bone (CB) MSCs have shown great potential
for use in orthopaedic surgery. CB MSCs exert powerful immunomodulatory effects in
addition to demonstrating excellent regenerative capacity for use in filling boney
defects. CB MSCs have been shown to have enhanced response to hypoxic conditions when
compared with other forms of MSCs. More work is needed to continue to characterize
the potential applications for CB MSCs in orthopaedic trauma.
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https://hdl.handle.net/10161/26286Published Version (Please cite this version)
10.4252/wjsc.v12.i11.1341Publication Info
Anastasio, Albert; Gergues, Marina; Lebhar, Michael S; Rameshwar, Pranela; & Fernandez-Moure,
Joseph (2020). Isolation and characterization of mesenchymal stem cells in orthopaedics and the emergence
of compact bone mesenchymal stem cells as a promising surgical adjunct. World journal of stem cells, 12(11). pp. 1341-1353. 10.4252/wjsc.v12.i11.1341. Retrieved from https://hdl.handle.net/10161/26286.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Joseph Steven Fernandez-Moure
Assistant Professor of Surgery

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