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Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling.

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Date
2020-07
Authors
Hu, Shiqi
Li, Zhenhua
Lutz, Halle
Huang, Ke
Su, Teng
Cores, Jhon
Dinh, Phuong-Uyen Cao
Cheng, Ke
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Abstract
The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid-derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid-derived exosomes up-regulated β-catenin, promoting the development of hair follicles.
Type
Journal article
Subject
Hair Follicle
Cells, Cultured
Hair
MicroRNAs
Regeneration
beta Catenin
Exosomes
Permalink
https://hdl.handle.net/10161/26305
Published Version (Please cite this version)
10.1126/sciadv.aba1685
Publication Info
Hu, Shiqi; Li, Zhenhua; Lutz, Halle; Huang, Ke; Su, Teng; Cores, Jhon; ... Cheng, Ke (2020). Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling. Science advances, 6(30). pp. eaba1685. 10.1126/sciadv.aba1685. Retrieved from https://hdl.handle.net/10161/26305.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Su

Teng Su

Assistant Professor in Medicine
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