Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling.
Abstract
The progression in the hair follicle cycle from the telogen to the anagen phase is
the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth
and regulate the hair cycle. However, they gradually lose key inductive properties
upon culture. DP cells can partially restore their capacity to promote hair regrowth
after being subjected to spheroid culture. In this study, results revealed that DP
spheroids are effective at inducing the progression of the hair follicle cycle from
telogen to anagen compared with just DP cell or minoxidil treatment. Because of the
importance of paracrine signaling in this process, secretome and exosomes were isolated
from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated
that miR-218-5p was notably up-regulated in DP spheroid-derived exosomes. Western
blot and immunofluorescence imaging were used to demonstrate that DP spheroid-derived
exosomes up-regulated β-catenin, promoting the development of hair follicles.
Type
Journal articlePermalink
https://hdl.handle.net/10161/26305Published Version (Please cite this version)
10.1126/sciadv.aba1685Publication Info
Hu, Shiqi; Li, Zhenhua; Lutz, Halle; Huang, Ke; Su, Teng; Cores, Jhon; ... Cheng,
Ke (2020). Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin
signaling. Science advances, 6(30). pp. eaba1685. 10.1126/sciadv.aba1685. Retrieved from https://hdl.handle.net/10161/26305.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Teng Su
Assistant Professor in Medicine

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