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Targeted anti-IL-1β platelet microparticles for cardiac detoxing and repair.
Abstract
An acute myocardial infarction (AMI) induces a sterile inflammatory response that
facilitates further heart injury and promotes adverse cardiac remodeling. Interleukin-1β
(IL-1β) plays a central role in the sterile inflammatory response that results from
AMI. Thus, IL-1β blockage is a promising strategy for treatment of AMI. However, conventional
IL-1β blockers lack targeting specificity. This increases the risk of serious side
effects. To address this problem herein, we fabricated platelet microparticles (PMs)
armed with anti-IL-1β antibodies to neutralize IL-1β after AMI and to prevent adverse
cardiac remodeling. Our results indicate that the infarct-targeting PMs could bind
to the injured heart, increasing the number of anti-IL-1β antibodies therein. The
anti-IL-1β platelet PMs (IL1-PMs) protect the cardiomyocytes from apoptosis by neutralizing
IL-1β and decreasing IL-1β-driven caspase-3 activity. Our findings indicate that IL1-PM
is a promising cardiac detoxification agent that removes cytotoxic IL-1β during AMI
and induces therapeutic cardiac repair.
Type
Journal articleSubject
Blood PlateletsMyocytes, Cardiac
Animals
Humans
Mice
Myocardial Infarction
Disease Models, Animal
Inflammation Mediators
Cytokines
Immunohistochemistry
Apoptosis
Protein Binding
Ventricular Remodeling
Models, Biological
Interleukin-1beta
Cell-Derived Microparticles
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https://hdl.handle.net/10161/26306Published Version (Please cite this version)
10.1126/sciadv.aay0589Publication Info
Li, Zhenhua; Hu, Shiqi; Huang, Ke; Su, Teng; Cores, Jhon; & Cheng, Ke (2020). Targeted anti-IL-1β platelet microparticles for cardiac detoxing and repair. Science advances, 6(6). pp. eaay0589. 10.1126/sciadv.aay0589. Retrieved from https://hdl.handle.net/10161/26306.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Teng Su
Assistant Professor in Medicine

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