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Exosome-eluting stents for vascular healing after ischaemic injury.

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Date
2021-10
Authors
Hu, Shiqi
Li, Zhenhua
Shen, Deliang
Zhu, Dashuai
Huang, Ke
Su, Teng
Dinh, Phuong-Uyen
Cores, Jhon
Cheng, Ke
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Abstract
Drug-eluting stents implanted after ischaemic injury reduce the proliferation of endothelial cells and vascular smooth muscle cells and thus neointimal hyperplasia. However, the eluted drug also slows down the re-endothelialization process, delays arterial healing and can increase the risk of late restenosis. Here we show that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells. Compared with drug-eluting stents and bare-metal stents, the exosome-coated stents accelerated re-endothelialization and decreased in-stent restenosis 28 days after implantation. We also show that exosome-eluting stents implanted in the abdominal aorta of rats with unilateral hindlimb ischaemia regulated macrophage polarization, reduced local vascular and systemic inflammation, and promoted muscle tissue repair.
Type
Journal article
Subject
Endothelium, Vascular
Endothelial Cells
Animals
Rats
Ischemia
Stents
Drug-Eluting Stents
Exosomes
Permalink
https://hdl.handle.net/10161/26313
Published Version (Please cite this version)
10.1038/s41551-021-00705-0
Publication Info
Hu, Shiqi; Li, Zhenhua; Shen, Deliang; Zhu, Dashuai; Huang, Ke; Su, Teng; ... Cheng, Ke (2021). Exosome-eluting stents for vascular healing after ischaemic injury. Nature biomedical engineering, 5(10). pp. 1174-1188. 10.1038/s41551-021-00705-0. Retrieved from https://hdl.handle.net/10161/26313.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Su

Teng Su

Assistant Professor in Medicine
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