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Exosome-eluting stents for vascular healing after ischaemic injury.
Abstract
Drug-eluting stents implanted after ischaemic injury reduce the proliferation of endothelial
cells and vascular smooth muscle cells and thus neointimal hyperplasia. However, the
eluted drug also slows down the re-endothelialization process, delays arterial healing
and can increase the risk of late restenosis. Here we show that stents releasing exosomes
derived from mesenchymal stem cells in the presence of reactive oxygen species enhance
vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial
cell tube formation and proliferation, and impairing the migration of smooth muscle
cells. Compared with drug-eluting stents and bare-metal stents, the exosome-coated
stents accelerated re-endothelialization and decreased in-stent restenosis 28 days
after implantation. We also show that exosome-eluting stents implanted in the abdominal
aorta of rats with unilateral hindlimb ischaemia regulated macrophage polarization,
reduced local vascular and systemic inflammation, and promoted muscle tissue repair.
Type
Journal articlePermalink
https://hdl.handle.net/10161/26313Published Version (Please cite this version)
10.1038/s41551-021-00705-0Publication Info
Hu, Shiqi; Li, Zhenhua; Shen, Deliang; Zhu, Dashuai; Huang, Ke; Su, Teng; ... Cheng,
Ke (2021). Exosome-eluting stents for vascular healing after ischaemic injury. Nature biomedical engineering, 5(10). pp. 1174-1188. 10.1038/s41551-021-00705-0. Retrieved from https://hdl.handle.net/10161/26313.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Teng Su
Assistant Professor in Medicine

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