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Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

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Date
2019-10-01
Authors
Huang, K
Li, Z
Su, T
Shen, D
Hu, S
Cheng, K
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Abstract
Bone marrow stem cells (BMSCs) are a promising strategy for cardiac regenerative therapy for myocardial infarction (MI). However, cell transplantation has to overcome a number of hurdles, such as cell quality control, clinical practicality, low cell retention/engraftment, and immune reactions when allogeneic cells are used. Bispecific antibodies (BsAbs) have been developed as potential agents in cancer immunotherapy but their application is sparse in cardiovascular diseases. In the present study, BsAbs are designed by chemical cycloaddition of F(ab′)2 fragments from monoclonal anti-CD34 and anti- cardiac myosin heavy chain (CMHC) antibodies, which specifically targets circulating CD34-positive cells and injured cardiomyocytes simultaneously. It is hypothesized that intravenous administration of stem cell re-directing (SCRD) BsAbs (anti-CD34-F(ab′)2–anti-CMHC-F(ab′)2) can home endogenous BMSCs to the injured heart for cardiac repair. The in vivo studies in a mouse model with heart ischemia/reperfusion (I/R) injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function.
Type
Journal article
Subject
bispecific antibodies
immunotherapy
myocardial infarction
stem cells
Permalink
https://hdl.handle.net/10161/26318
Published Version (Please cite this version)
10.1002/adtp.201900009
Publication Info
Huang, K; Li, Z; Su, T; Shen, D; Hu, S; & Cheng, K (2019). Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells. Advanced Therapeutics, 2(10). pp. 1900009-1900009. 10.1002/adtp.201900009. Retrieved from https://hdl.handle.net/10161/26318.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Su

Teng Su

Assistant Professor in Medicine
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