Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome.
Abstract
Stem cell therapies have made strides toward the efficacious treatment of injured
endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS).
Despite this progress, they are limited by their risk of tumor formation, low engraftment
rates, as well as storage and transportation logistics. While attempts have been made
to curb these issues, there remains a need for simple and effective solutions. A growing
body of evidence supports the theory that delivering media, conditioned with mesenchymal
stem cells, might be a promising alternative to live cell therapy. Mesenchymal stem
cell-secretome (MSC-Sec) has a superior safety profile and can be stored without losing
its regenerative properties. It is versatile enough to be added to a number of delivery
vehicles that improve engraftment and control the release of the therapeutic. Thus,
it holds great potential for the treatment of AS. Here, a new strategy for loading
crosslinked hyaluronic acid gel (HA gel) with MSC-Sec is reported. The HA gel/MSC-Sec
treatment paradigm creates a sustained release system that repairs endometrial injury
in rats and promotes viable pregnancy.
Type
Journal articleSubject
EndometriumMesenchymal Stem Cells
Animals
Humans
Rats, Sprague-Dawley
Gynatresia
Disease Models, Animal
Hyaluronic Acid
Hydrogels
Electrocoagulation
Pregnancy
Female
Human Umbilical Vein Endothelial Cells
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https://hdl.handle.net/10161/26320Published Version (Please cite this version)
10.1002/adhm.201900411Publication Info
Liu, Feiran; Hu, Shiqi; Yang, Hua; Li, Zhenhua; Huang, Ke; Su, Teng; ... Cheng, Ke (2019). Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat
Endometrial Injury in a Rat Model of Asherman's Syndrome. Advanced healthcare materials, 8(14). pp. e1900411. 10.1002/adhm.201900411. Retrieved from https://hdl.handle.net/10161/26320.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Teng Su
Assistant Professor in Medicine

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