Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.
Abstract
Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion
therapy is vital for patient survival post-heart attack, it also causes further tissue
injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice.
Exploring ways to attenuate I/R injury is of clinical interest for improving post-ischemic
recovery. A platelet-inspired nanocell (PINC) that incorporates both prostaglandin
E2 (PGE2)-modified platelet membrane and cardiac stromal cell-secreted factors to
target the heart after I/R injury is introduced. By taking advantage of the natural
infarct-homing ability of platelet membrane and the overexpression of PGE2 receptors
(EPs) in the pathological cardiac microenvironment after I/R injury, the PINCs can
achieve targeted delivery of therapeutic payload to the injured heart. Furthermore,
a synergistic treatment efficacy can be achieved by PINC, which combines the paracrine
mechanism of cell therapy with the PGE2/EP receptor signaling that is involved in
the repair and regeneration of multiple tissues. In a mouse model of myocardial I/R
injury, intravenous injection of PINCs results in augmented cardiac function and mitigated
heart remodeling, which is accompanied by the increase in cycling cardiomyocytes,
activation of endogenous stem/progenitor cells, and promotion of angiogenesis. This
approach represents a promising therapeutic delivery platform for treating I/R injury.
Type
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https://hdl.handle.net/10161/26323Published Version (Please cite this version)
10.1002/adfm.201803567Publication Info
Su, Teng; Huang, Ke; Ma, Hong; Liang, Hongxia; Dinh, Phuong-Uyen; Chen, Justin; ...
Cheng, Ke (2019). Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.
Advanced functional materials, 29(4). pp. 1803567. 10.1002/adfm.201803567. Retrieved from https://hdl.handle.net/10161/26323.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Tyler Allen
Affiliate
Teng Su
Assistant Professor in Medicine
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