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Targeted repair of heart injury by stem cells fused with platelet nanovesicles.

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Date
2018-01
Authors
Tang, Junnan
Su, Teng
Huang, Ke
Dinh, Phuong-Uyen
Wang, Zegen
Vandergriff, Adam
Hensley, Michael T
Cores, Jhon
Allen, Tyler
Li, Taosheng
Sproul, Erin
Mihalko, Emily
Lobo, Leonard J
Ruterbories, Laura
Lynch, Alex
Brown, Ashley
Caranasos, Thomas G
Shen, Deliang
Stouffer, George A
Gu, Zhen
Zhang, Jinying
Cheng, Ke
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(22 total)
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Abstract
Stem cell transplantation, as used clinically, suffers from low retention and engraftment of the transplanted cells. Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, we hypothesized that platelets might enhance the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction injury. Here, we show that CSCs with platelet nanovesicles fused onto their surface membranes express platelet surface markers that are associated with platelet adhesion to injury sites. We also find that the modified CSCs selectively bind collagen-coated surfaces and endothelium-denuded rat aortas, and that in rat and porcine models of acute myocardial infarction the modified CSCs increase retention in the heart and reduce infarct size. Platelet-nanovesicle-fused CSCs thus possess the natural targeting and repairing ability of their parental cell types. This stem cell manipulation approach is fast, straightforward and safe, does not require genetic alteration of the cells, and should be generalizable to multiple cell types.
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Journal article
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https://hdl.handle.net/10161/26328
Published Version (Please cite this version)
10.1038/s41551-017-0182-x
Publication Info
Tang, Junnan; Su, Teng; Huang, Ke; Dinh, Phuong-Uyen; Wang, Zegen; Vandergriff, Adam; ... Cheng, Ke (2018). Targeted repair of heart injury by stem cells fused with platelet nanovesicles. Nature biomedical engineering, 2(1). pp. 17-26. 10.1038/s41551-017-0182-x. Retrieved from https://hdl.handle.net/10161/26328.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Su

Teng Su

Assistant Professor in Medicine
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