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Targeted repair of heart injury by stem cells fused with platelet nanovesicles.
Abstract
Stem cell transplantation, as used clinically, suffers from low retention and engraftment
of the transplanted cells. Inspired by the ability of platelets to recruit stem cells
to sites of injury on blood vessels, we hypothesized that platelets might enhance
the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction
injury. Here, we show that CSCs with platelet nanovesicles fused onto their surface
membranes express platelet surface markers that are associated with platelet adhesion
to injury sites. We also find that the modified CSCs selectively bind collagen-coated
surfaces and endothelium-denuded rat aortas, and that in rat and porcine models of
acute myocardial infarction the modified CSCs increase retention in the heart and
reduce infarct size. Platelet-nanovesicle-fused CSCs thus possess the natural targeting
and repairing ability of their parental cell types. This stem cell manipulation approach
is fast, straightforward and safe, does not require genetic alteration of the cells,
and should be generalizable to multiple cell types.
Type
Journal articlePermalink
https://hdl.handle.net/10161/26328Published Version (Please cite this version)
10.1038/s41551-017-0182-xPublication Info
Tang, Junnan; Su, Teng; Huang, Ke; Dinh, Phuong-Uyen; Wang, Zegen; Vandergriff, Adam;
... Cheng, Ke (2018). Targeted repair of heart injury by stem cells fused with platelet nanovesicles. Nature biomedical engineering, 2(1). pp. 17-26. 10.1038/s41551-017-0182-x. Retrieved from https://hdl.handle.net/10161/26328.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Tyler Allen
Affiliate
Teng Su
Assistant Professor in Medicine
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