Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents.
Abstract
This work described a proof of concept study of hybrid nanogel-based magnetic resonance
contrast agents, SPIO@GCS/acryl/biotin@Mn-gel, abb. as SGM, for highly efficient,
pH-responsive T1 and T2 dual-mode magnetic resonance imaging (MRI). SGM have been
synthesized by assembling superparamagnetic iron oxide particles into polysaccharide
nanoclusters, followed by in-situ reduction of the manganese species on the clusters
and a final mild polymerization. The dual-mode SGM showed an interesting pH-responsiveness
in in vitro MRI, with both T1 and T2 relaxivities turned "ON" in the acidic environment,
along with an increase in the r1 and r2 relaxivity values by 1.7-fold (from 8.9 to
15.3 mM(-1) S(-1)) and 4.9-fold (from 45.7 to 226 mM(-1) S(-1)), due to desirable
silencing and de-silencing effects. This interesting acidic-responsiveness was further
verified in vivo with both significantly brightened signal of tumor tissue in T1-weighted
MR images and a darkened signal in T2-weighted MR images 50 min post-injection of
SGM. This smart hybrid nanogel may serve as a promising candidate for further studies
of dual-mode (T1 and T2) contrast agents in MRI, due to its high stability, interesting
pH-response mechanism and indicative imaging of tumors.
Type
Journal articleSubject
AnimalsHumans
Mice
Mice, Nude
Oxides
Ferric Compounds
Manganese Compounds
Gels
Contrast Media
Magnetic Resonance Imaging
Hydrogen-Ion Concentration
Nanotechnology
Female
Hep G2 Cells
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https://hdl.handle.net/10161/26331Published Version (Please cite this version)
10.1016/j.biomaterials.2015.02.101Publication Info
Wang, Xia; Niu, Dechao; Wu, Qing; Bao, Song; Su, Teng; Liu, Xiaohang; ... Wang, Qigang (2015). Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance
contrast agents. Biomaterials, 53. pp. 349-357. 10.1016/j.biomaterials.2015.02.101. Retrieved from https://hdl.handle.net/10161/26331.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Teng Su
Assistant Professor in Medicine

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