Glucose oxidase triggers gelation of N-hydroxyimide-heparin conjugates to form enzyme-responsive hydrogels for cell-specific drug delivery
Abstract
A new strategy for creating enzyme-responsive hydrogels by employing an N-hydroxyimide-heparin
conjugate, designed to act as both an enzyme-mediated radical initiator and an enzyme-sensitive
therapeutic carrier, is described. A novel enzyme-mediated redox initiation system
involving glucose oxidase (GOx), an N-hydroxyimide-heparin conjugate and glucose is
reported. The GOx-mediated radical polymerization reaction allows quick formation
of hydrogels under mild conditions, with excellent flexibility in the modulation of
the physical and chemical characteristics. The heparin-specific enzymatic cleavage
reaction enables the delivery of cargo from the hydrogel in amounts that are controlled
by the environmental levels of heparanase, which is frequently associated with tumor
angiogenesis and metastasis. The formed hydrogels can realize cell-specific drug delivery
by targeting cancer cells that are characterized by heparanase overexpression, whilst
showing little toxicity towards normal cells. This journal is
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https://hdl.handle.net/10161/26336Published Version (Please cite this version)
10.1039/c4sc01603cPublication Info
Su, T; Tang, Z; He, H; Li, W; Wang, X; Liao, C; ... Wang, Q (2014). Glucose oxidase triggers gelation of N-hydroxyimide-heparin conjugates to form enzyme-responsive
hydrogels for cell-specific drug delivery. Chemical Science, 5(11). pp. 4204-4209. 10.1039/c4sc01603c. Retrieved from https://hdl.handle.net/10161/26336.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Teng Su
Assistant Professor in Medicine

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