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Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

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Date
2021-08
Authors
Kuriakose, Safia
Singh, Kanal
Pau, Alice K
Daar, Eric
Gandhi, Rajesh
Tebas, Pablo
Evans, Laura
Gulick, Roy M
Lane, H Clifford
Masur, Henry
NIH COVID-19 Treatment Guidelines Panel
Aberg, Judith A
Adimora, Adaora A
Baker, Jason
Kreuziger, Lisa Baumann
Bedimo, Roger
Belperio, Pamela S
Cantrill, Stephen V
Coopersmith, Craig M
Davis, Susan L
Dzierba, Amy L
Gallagher, John J
Glidden, David V
Grund, Birgit
Hardy, Erica J
Hinkson, Carl
Hughes, Brenna L
Johnson, Steven
Keller, Marla J
Kim, Arthur Y
Lennox, Jeffrey L
Levy, Mitchell M
Li, Jonathan Z
Martin, Greg S
Naggie, Susanna
Pavia, Andrew T
Seam, Nitin
Simpson, Steven Q
Swindells, Susan
Tien, Phyllis
Waghmare, Alpana A
Wilson, Kevin C
Yazdany, Jinoos
Zachariah, Philip
Campbell, Danielle M
Harrison, Carly
Burgess, Timothy
Francis, Joseph
Sheikh, Virginia
Uyeki, Timothy M
Walker, Robert
Brooks, John T
Ortiz, Laura Bosque
Davey, Richard T
Doepel, Laurie K
Eisinger, Robert W
Han, Alison
Higgs, Elizabeth S
Nason, Martha C
Crew, Page
Lerner, Andrea M
Lund, Claire
Worthington, Christopher
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Abstract
The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did subsequent meetings). The Panel comprises 57 individuals representing 6 governmental agencies, 11 professional societies, and 33 medical centers, plus 2 community members, who have worked together to create and frequently update the guidelines on the basis of evidence from the most recent clinical studies available. The initial version of the guidelines was completed within 2 weeks and posted online on 21 April 2020. Initially, sparse evidence was available to guide COVID-19 treatment recommendations. However, treatment data rapidly accrued based on results from clinical studies that used various study designs and evaluated different therapeutic agents and approaches. Data have continued to evolve at a rapid pace, leading to 24 revisions and updates of the guidelines in the first year. This process has provided important lessons for responding to an unprecedented public health emergency: Providers and stakeholders are eager to access credible, current treatment guidelines; governmental agencies, professional societies, and health care leaders can work together effectively and expeditiously; panelists from various disciplines, including biostatistics, are important for quickly developing well-informed recommendations; well-powered randomized clinical trials continue to provide the most compelling evidence to guide treatment recommendations; treatment recommendations need to be developed in a confidential setting free from external pressures; development of a user-friendly, web-based format for communicating with health care providers requires substantial administrative support; and frequent updates are necessary as clinical evidence rapidly emerges.
Type
Journal article
Subject
NIH COVID-19 Treatment Guidelines Panel
Humans
Data Interpretation, Statistical
Drug Approval
Interprofessional Relations
Evidence-Based Medicine
Pregnancy
National Institutes of Health (U.S.)
Child
Advisory Committees
United States
Female
Practice Guidelines as Topic
Pandemics
Stakeholder Participation
COVID-19
SARS-CoV-2
Permalink
https://hdl.handle.net/10161/26426
Published Version (Please cite this version)
10.7326/m21-1647
Publication Info
Kuriakose, Safia; Singh, Kanal; Pau, Alice K; Daar, Eric; Gandhi, Rajesh; Tebas, Pablo; ... Worthington, Christopher (2021). Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19. Annals of internal medicine, 174(8). pp. 1151-1158. 10.7326/m21-1647. Retrieved from https://hdl.handle.net/10161/26426.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Hughes

Brenna L Hughes

Associate Professor of Obstetrics and Gynecology
Naggie

Susanna Naggie

Professor of Medicine
Dr. Susanna Naggie completed her medical education at Johns Hopkins School of Medicine and her internal medicine training at Duke University Medical Center (DUMC), where she also served as a Chief Resident in Internal Medicine.  She completed her Infectious Diseases (ID) fellowship training at Duke and then joined the faculty in the Division of ID. She is a Professor of Medicine and currently holds joint appointments at the Duke Clinical Research Institute and at the Durham Veterans Affa
Alphabetical list of authors with Scholars@Duke profiles.
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