Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma
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https://hdl.handle.net/10161/26559Published Version (Please cite this version)
10.1172/jci70712Publication Info
Bianchi-Smiraglia, Anna; Bagati, Archis; Fink, Emily E; Affronti, Hayley C; Lipchick,
Brittany C; Moparthy, Sudha; ... Nikiforov, Mikhail A (2018). Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses
multiple myeloma. Journal of Clinical Investigation, 128(10). pp. 4682-4696. 10.1172/jci70712. Retrieved from https://hdl.handle.net/10161/26559.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Mikhail A. Nikiforov
Professor of Pathology
Mechanism of Deregulated GTP Metabolism in Cancer Cells
GTP-binding proteins (G proteins) regulate a vast variety of cellular processes and
are frequently hyper-activated in human cancers. Enzymes controlling the de novo biosynthesis
of GTP are also substantially deregulated during tumorigenesis and metastasis. Historically,
changes in GTP levels were not considered as a regulatory step in activation of G-proteins
in live cells. This is because average intracellular GTP concentration

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