Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

Bianchi-Smiraglia, Anna; Bagati, Archis; Fink, Emily E; Affronti, Hayley C; Lipchick, Brittany C; Moparthy, Sudha; Long, Mark D; Rosario, Spencer R; Lightman, Shivana M; Moparthy, Kalyana; Wolff, David W; Yun, Dong Hyun; Han, Zhannan; Polechetti, Anthony; Roll, Matthew V; Gitlin, Ilya I; Leonova, Katerina I; Rowsam, Aryn M; Kandel, Eugene S; Gudkov, Andrei V; Bergsagel, P Leif; Lee, Kelvin P; Smiraglia, Dominic J; Nikiforov, Mikhail A

doi:10.1172/jci70712

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https://hdl.handle.net/10161/26559

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10.1172/jci70712

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Bianchi-Smiraglia, Anna; Bagati, Archis; Fink, Emily E; Affronti, Hayley C; Lipchick, Brittany C; Moparthy, Sudha; ... Nikiforov, Mikhail A (2018). Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma. Journal of Clinical Investigation, 128(10). pp. 4682-4696. 10.1172/jci70712. Retrieved from https://hdl.handle.net/10161/26559.

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Scholars@Duke

Mikhail A. Nikiforov

Professor of Pathology

Mechanism of Deregulated GTP Metabolism in Cancer Cells GTP-binding proteins (G proteins) regulate a vast variety of cellular processes and are frequently hyper-activated in human cancers. Enzymes controlling the de novo biosynthesis of GTP are also substantially deregulated during tumorigenesis and metastasis. Historically, changes in GTP levels were not considered as a regulatory step in activation of G-proteins in live cells. This is because average intracellular GTP concentration

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