The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.
Abstract
<h4>Introduction</h4>The disease origins of idiopathic pulmonary fibrosis (IPF), which
occurs at higher rates in certain races/ethnicities, are not understood. The highest
rates occur in white persons of European descent, particularly those with light skin,
who are also susceptible to lysosomal organelle dysfunction of the skin leading to
fibroproliferative disease . We had observed clinically that the vast majority of
patients with IPF had light-colored eyes, suggesting a phenotypic characteristic.<h4>Methods</h4>We
pursued this observation through a research database from the USA Veterans Administration,
a population that has a high occurrence of IPF due to predominance of elderly male
smokers. Using this medical records database, which included facial photos, we compared
the frequency of light (blue, green, hazel) and dark (light brown, brown) eyes among
white patients diagnosed with IPF compared with a control group of lung granuloma
only (no other radiologic evidence of interstitial lung disease).<h4>Results</h4>Light
eye color was significantly more prevalent in patients with IPF than in the control
group with lung granuloma [114/147 (77.6%) versus 129/263 (49.0%], p < 0.001), indicating
that light-colored eyes are a phenotype associated with IPF .<h4>Conclusion</h4>We
provide evidence that light eye color is predominant among white persons with IPF.
Type
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https://hdl.handle.net/10161/26626Published Version (Please cite this version)
10.1007/s41030-022-00198-5Publication Info
Pleasants, Roy A; Bedoya, Armando D; Boggan, Joel M; Welty-Wolf, Karen; & Tighe, Robert
M (2022). The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation. Pulmonary therapy, 8(3). pp. 327-331. 10.1007/s41030-022-00198-5. Retrieved from https://hdl.handle.net/10161/26626.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Armando Diego Bedoya
Assistant Professor of Medicine
Joel Boggan
Associate Professor of Medicine
I am a hospital medicine physician interested in quality improvement, patient safety,
and medical education across the UME, GME, and CME environments. My current QI and
research projects include work on readmissions, inpatient ORYX and patient experience
measures, clinical documentation improvement, medication reconciliation, and appropriate
utilization of inpatient resources. Alongside this work, I serve as the lead mentor
for our Durham VA Chief Resident in Quality and Safety within the Depart
Robert Matthew Tighe
Associate Professor of Medicine
The research focus of the Tighe laboratory is performing pulmonary basic-translational
studies to define mechanisms of susceptibility to lung injury and disease. There are
three principal focus areas. These include: 1) Identifying susceptibility factors
and candidate pathways relevant to host biological responses to environmental pollutants
such as ozone, woodsmoke and silica, 2) Defining protective and detrimental functions
of lung macrophage subsets and their cross talk with the epithelium
Karen Elizabeth Welty-Wolf
Professor of Medicine
Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and
(2) multiple organ failure and disordered energy metabolism in sepsis. Injury models
include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis.
In addition to evaluating mechanisms of lung injury in sepsis, current studies are
being conducted to evaluate the potential role of monoclinal antibodies to neutrophil
adhesion molecules in the prevention of this injury. Other sepsis work inc
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