SGC-CAMKK2-1: A Chemical Probe for CAMKK2.
Abstract
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase
2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance,
only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small
molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition
can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical
probe that targets CAMKK2.
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https://hdl.handle.net/10161/26665Published Version (Please cite this version)
10.3390/cells12020287Publication Info
(2023). SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Cells, 12(2). pp. 287. 10.3390/cells12020287. Retrieved from https://hdl.handle.net/10161/26665.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Donald Patrick McDonnell
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School
of Medicine
The research in our group is focused on the development and application of mechanism
based approaches to identify novel therapeutics for use in the treatment and prevention
of hormonally responsive cancers. Specifically we are interested in the pharmaceutical
exploitation of the estrogen and androgen receptors as therapeutic targets in breast
and prostate cancers and in defining how these receptors influence the pathogenesis
of these diseases. These efforts have led to the discovery of severa
Luigi Racioppi
Associate Professor in Medicine
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