Now showing items 21-40 of 12389

    • The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates. 

      Li, Dapeng; Edwards, Robert J; Manne, Kartik; Martinez, David R; Schäfer, Alexandra; Alam, S Munir; Wiehe, Kevin; ... (64 authors) (bioRxiv, 2021-02-18)
      SARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated NAbs against the receptor-binding domain (RBD) ...
    • A corporate plantation reading public: Labor, literacy, and diaspora in the global black South 

      McInnis, JC (American Literature, 2019-09-01)
      This essay reconstructs the history of the Cotton Farmer, a rare African American newspaper edited and published by black tenant farmers employed by the Delta and Pine Land Company, once the world’s largest corporate cotton ...
    • Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses. 

      Saunders, Kevin O; Lee, Esther; Parks, Robert; Martinez, David R; Li, Dapeng; Chen, Haiyan; Edwards, Robert J; ... (49 authors) (Nature, 2021-06)
      Betacoronaviruses caused the outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, as well as the current pandemic of SARS coronavirus 2 (SARS-CoV-2)1-4. Vaccines that elicit protective ...
    • In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies 

      Li, Dapeng; Edwards, Robert J; Manne, Kartik; Martinez, David R; Schäfer, Alexandra; Alam, S Munir; Wiehe, Kevin; ... (11 authors) (Cell, 2021)
      SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated NAbs against the receptor-binding domain (RBD) ...
    • Black Women's Geographies and the Afterlives of the Sugar Plantation 

      Mcinnis, JC (American Literary History, 2019-12-01)
      <jats:title>Abstract</jats:title> <jats:p>This essay examines how several contemporary black women artists—Attica Locke, Natalie Baszile, Beyoncé, Ava DuVernay, and Kara Walker—interrogate the afterlives of ...
    • SARS-CoV-2 Viremia is Associated with COVID-19 Severity and Predicts Clinical Outcomes. 

      Jacobs, Jana L; Bain, William; Naqvi, Asma; Staines, Brittany; Castanha, Priscila MS; Yang, Haopu; Boltz, Valerie F; ... (27 authors) (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08-10)
      <h4>Background</h4>SARS-CoV-2 viral RNA (vRNA) is detected in the bloodstream of some patients with COVID-19 ("RNAemia") but it is not clear whether this RNAemia reflects viremia (i.e., virus particles) and how RNAemia/viremia ...
    • Evaluation of Commercially Available High-Throughput SARS-CoV-2 Serologic Assays for Serosurveillance and Related Applications. 

      Stone, Mars; Grebe, Eduard; Sulaeman, Hasan; Di Germanio, Clara; Dave, Honey; Kelly, Kathleen; Biggerstaff, Brad J; ... (20 authors) (Emerging infectious diseases, 2022-03)
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurveys can estimate cumulative incidence for monitoring epidemics, requiring assessment of serologic assays to inform testing algorithm development ...
    • Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion. 

      Giroux, Nicholas S; Ding, Shengli; McClain, Micah T; Burke, Thomas W; Petzold, Elizabeth; Chung, Hong A; Rivera, Grecia O; ... (24 authors) (Res Sq, 2022-04-07)
      SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease ...
    • Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency. 

      Moghnie, Sara; Tovmasyan, Artak; Craik, James; Batinic-Haberle, Ines; Benov, Ludmil (Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2017-11)
      Photodynamic therapy (PDT) is a promising alternative approach particularly attractive for treatment of localized fungal infections. It is based on compounds, photosensitizers (PSs), which when excited with visible light, ...
    • The Opioid Use Disorder Core Outcomes Set (OUD-COS) for treatment research: findings from a Delphi consensus study. 

      Karnik, Niranjan S; Marsden, John; McCluskey, Connor; Boley, Randy A; Bradley, Katharine A; Campbell, Cynthia I; Curtis, Megan E; ... (23 authors) (Addiction (Abingdon, England), 2022-03-16)
      <h4>Background and aim</h4>There is no gold-standard and considerable heterogeneity in outcome measures used to evaluate treatments for opioid use disorder (OUD) along the opioid treatment cascade. The aim of this study ...
    • Engaging Researchers in Data Dialogues: Designing Collaborative Programming to Promote Research Data Sharing 

      Downey, Moira; Lafferty-Hess, Sophia; Charbonneau, Patrick; Zoss, Angela
      <jats:p>A range of regulatory pressures emanating from funding agencies and scholarly journals increasingly encourage researchers to engage in formal data sharing practices. As academic libraries continue to refine their ...
    • Correction to: Obtaining Soft Matter Models of Proteins and their Phase Behavior. 

      Altan, Irem; Charbonneau, Patrick (Methods in molecular biology (Clifton, N.J.), 2019-01)
      The acknowledgement section text has been updated in the chapter.
    • Obtaining Soft Matter Models of Proteins and their Phase Behavior. 

      Altan, Irem; Charbonneau, Patrick (Methods in molecular biology (Clifton, N.J.), 2019-01)
      Globular proteins are roughly spherical biomolecules with attractive and highly directional interactions. This microscopic observation motivates describing these proteins as patchy particles: hard spheres with attractive ...
    • The dimensional evolution of structure and dynamics in hard sphere liquids. 

      Charbonneau, Patrick; Hu, Yi; Kundu, Joyjit; Morse, Peter K (The Journal of chemical physics, 2022-04)
      The formulation of the mean-field infinite-dimensional solution of hard sphere glasses is a significant milestone for theoretical physics. How relevant this description might be for understanding low-dimensional glass-forming ...
    • Learning about Biomolecular Solvation from Water in Protein Crystals. 

      Altan, Irem; Fusco, Diana; Afonine, Pavel V; Charbonneau, Patrick (The journal of physical chemistry. B, 2018-03)
      Water occupies typically 50% of a protein crystal and thus significantly contributes to the diffraction signal in crystallography experiments. Separating its contribution from that of the protein is, however, challenging ...
    • Using Schematic Models to Understand the Microscopic Basis for Inverted Solubility in γD-Crystallin. 

      Altan, Irem; Khan, Amir R; James, Susan; Quinn, Michelle K; McManus, Jennifer J; Charbonneau, Patrick (The journal of physical chemistry. B, 2019-11)
      Inverted solubility-melting a crystal by cooling-is observed in a handful of proteins, such as carbomonoxy hemoglobin C and γD-crystallin. In human γD-crystallin, the phenomenon is associated with the mutation of the 23rd ...
    • Local dynamical heterogeneity in glass formers 

      Biroli, Giulio; Charbonneau, Patrick; Folena, Giampaolo; Hu, Yi; Zamponi, Francesco (2021-09-24)
      We study the local dynamical fluctuations in glass-forming models of particles embedded in $d$-dimensional space, in the mean-field limit of $d\to\infty$. Our analytical calculation reveals that single-particle observables, ...
    • Gardner physics in amorphous solids and beyond. 

      Berthier, Ludovic; Biroli, Giulio; Charbonneau, Patrick; Corwin, Eric I; Franz, Silvio; Zamponi, Francesco (The Journal of chemical physics, 2019-07)
      One of the most remarkable predictions to emerge out of the exact infinite-dimensional solution of the glass problem is the Gardner transition. Although this transition was first theoretically proposed a generation ago for ...
    • Front-Mediated Melting of Isotropic Ultrastable Glasses. 

      Flenner, Elijah; Berthier, Ludovic; Charbonneau, Patrick; Fullerton, Christopher J (Physical review letters, 2019-10)
      Ultrastable vapor-deposited glasses display uncommon material properties. Most remarkably, upon heating they are believed to melt via a liquid front that originates at the free surface and propagates over a mesoscopic crossover ...
    • Postponing the dynamical transition density using competing interactions 

      Charbonneau, P; Kundu, J (Granular Matter, 2020-08-01)
      Systems of dense spheres interacting through very short-ranged attraction are known from theory, simulations and colloidal experiments to exhibit dynamical reentrance. Their liquid state can thus be fluidized at higher densities ...