Browsing Duke Scholarly Works by Affiliation of Duke Author(s) "Center for Population Health & Aging"
Now showing items 1-20 of 269
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A Decad(e) of Reasons to Contribute to a PLOS Community-Run Journal
(PLOS Genetics, 2015-10-05) -
A life-history evaluation of the impact of maternal effects on recruitment and fisheries reference points
(Canadian Journal of Fisheries and Aquatic Sciences, 2014-01-01)Fishing causes dramatic changes in the age and size structure of fish stocks. In particular, the targeting of the largest and oldest individuals in a stock changes the age and size distribution of that stock. A large female ... -
A longitudinal study of epigenetic variation in twins.
(Epigenetics, 2010-08-16)DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been ... -
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
(J Gerontol A Biol Sci Med Sci, 2010-05)BACKGROUND: Genome-wide association studies (GWAS) may yield insights into longevity. METHODS: We performed a meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibi... -
A new algorithm for predicting time to disease endpoints in Alzheimer's disease patients.
(J Alzheimers Dis, 2014)BACKGROUND: The ability to predict the length of time to death and institutionalization has strong implications for Alzheimer's disease patients and caregivers, health policy, economics, and the design of intervention studies. ... -
Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging.
(Am J Psychiatry, 2002-06)OBJECTIVE: The authors sought to increase understanding of the brain mechanisms involved in cigarette addiction by identifying neural substrates modulated by visual smoking cues in nicotine-deprived smokers. METHOD: Event-related ... -
Activity of mannose-binding lectin in centenarians
(Aging Cell, 2012-06) -
Adherence to diabetes guidelines for screening, physical activity and medication and onset of complications and death.
(J Diabetes Complications, 2015-11)AIMS: Analyze relationships between adherence to guidelines for diabetes care - regular screening; physical activity; and medication - and diabetes complications and mortality. METHODS: Outcomes were onset of congestive ... -
Adult age differences in functional connectivity during executive control.
(Neuroimage, 2010-08-15)Task switching requires executive control processes that undergo age-related decline. Previous neuroimaging studies have identified age-related differences in brain activation associated with global switching effects (dual-task ... -
Advancing Geriatrics Education Through a Faculty Development Program for Geriatrics-Oriented Clinician Educators.
(J Am Geriatr Soc, 2015-12)Geriatrician and nongeriatrician faculty need instruction as teachers to provide quality training for a broader community of physicians who can care for the expanding population of older adults. Educators at Duke University ... -
Age mediation of frontoparietal activation during visual feature search.
(Neuroimage, 2014-11-15)Activation of frontal and parietal brain regions is associated with attentional control during visual search. We used fMRI to characterize age-related differences in frontoparietal activation in a highly efficient feature ... -
Age patterns of incidence of geriatric disease in the U.S. elderly population: Medicare-based analysis.
(J Am Geriatr Soc, 2012-02)OBJECTIVES: To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population. DESIGN: Age-specific incidence rates of 19 aging-related diseases ... -
Age trajectories of physiological indices in relation to healthy life course.
(Mech Ageing Dev, 2011-03)We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, ... -
Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan
(PLoS Genetics, 2014-01-01)Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ... -
Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
(PLoS Genet, 2014-01)Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ... -
Age-Associated Disorders As A Proxy Measure Of Biological Age: Findings From the NLTCS Data
(2017-06-07)Background: The relative contribution of different aging-associated processes to the age phenotype may differ among individuals, creating variability in aging manifestations among age-peers. Capturing this variability can ... -
Age-related effects on the neural correlates of autobiographical memory retrieval.
(Neurobiol Aging, 2012-07)Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases ... -
Aging and health--a systems biology perspective. Introduction.
(Interdiscip Top Gerontol, 2015) -
An age-structured extension to the vectorial capacity model.
(PLoS One, 2012)BACKGROUND: Vectorial capacity and the basic reproductive number (R(0)) have been instrumental in structuring thinking about vector-borne pathogen transmission and how best to prevent the diseases they cause. One of the ... -
Are for-profit hospital conversions harmful to patients and to Medicare?
(Rand J Econ, 2002)We examine how changes in hospital ownership to and from for-profit status affect quality and Medicare payments per hospital stay. We hypothesize that hospitals converting to for-profit ownership boost post acquisition ...
