Browsing Duke Scholarly Works by Affiliation of Duke Author(s) "Chemistry"
Now showing items 1-20 of 448
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(15)N Hyperpolarization of Imidazole-(15)N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH.
(ACS Sens, 2016-06-24)(15)N nuclear spins of imidazole-(15)N2 were hyperpolarized using NMR signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH). A (15)N NMR signal enhancement of ∼2000-fold ... -
A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.
(Proc Natl Acad Sci U S A, 1993-02-15)We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document ... -
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
(Proc Natl Acad Sci U S A, 1998-07-21)The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange. NHERF contains two PDZ domains, the first of which is required ... -
A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer.
(PloS one, 2018-01)Computed tomography (CT) is the standard imaging test used for the screening and assessment of suspected lung cancer, but distinguishing malignant from benign nodules by CT is an ongoing challenge. Consequently, a large ... -
A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.
(Proc Natl Acad Sci U S A, 1994-03-29)The beta 2-adrenergic receptor (beta 2AR) can be constitutively activated by mutations in the third intracellular loop. Whereas the wild-type receptor exists predominantly in an inactive conformation (R) in the absence of ... -
A convergent method for linear half-space kinetic equations
(2017-04-23)We give a unified proof for the well-posedness of a class of linear half-space equations with general incoming data and construct a Galerkin method to numerically resolve this type of equations in a systematic way. Our main ... -
A Diabatic Surface Hopping Algorithm based on Time Dependent Perturbation Theory and Semiclassical Analysis
(2017-11-30)Surface hopping algorithms are popular tools to study dynamics of the quantum-classical mixed systems. In this paper, we propose a surface hopping algorithm in diabatic representations, based on time dependent perturbation ... -
A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation.
(J Control Release, 2013-10-10)Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic ... -
A highly sensitive Raman method for selective cyanide detection based on evaporated cuprous iodide substrate
(Analytical Methods, 2010-05-01)A strong interaction between cyanide anion and copper(i) cation in combination with non-resonant Raman fingerprinting allows the selective sensing of aqueous free cynanide with high sensitivity to parts per billion (ppb)-level. ... -
A Hybrid Global-local Numerical Method for Multiscale PDEs
(2017-04-23)We present a new hybrid numerical method for multiscale partial differential equations, which simultaneously captures both the global macroscopic information and resolves the local microscopic events. The convergence of ... -
A hybrid ion-atom trap with integrated high resolution mass spectrometer
(Review of Scientific Instruments, 2019-10-01)© 2019 Author(s). In this article, we describe the design, construction, and implementation of our ion-atom hybrid system incorporating a high resolution time of flight mass spectrometer (TOFMS). Potassium atoms (39K) in ... -
A magnificent time with the "magnificent seven" transmembrane spanning receptors.
(Circ Res, 2003-03-07) -
A Mathematical Theory of Optimal Milestoning (with a Detour via Exact Milestoning)
(2017-04-23)Milestoning is a computational procedure that reduces the dynamics of complex systems to memoryless jumps between intermediates, or milestones, and only retains some information about the probability of these jumps and the ... -
A microscopic model of the Stokes-Einstein relation in arbitrary dimension.
(The Journal of chemical physics, 2018-06)The Stokes-Einstein relation (SER) is one of the most robust and widely employed results from the theory of liquids. Yet sizable deviations can be observed for self-solvation, which cannot be explained by the standard ... -
A nontrivial critical fixed point for replica-symmetry-breaking transitions
(2017-04-01)The transformation of the free-energy landscape from smooth to hierarchical is one of the richest features of mean-field disordered systems. A well-studied example is the de Almeida-Thouless transition for spin glasses in ... -
A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.
(Theranostics, 2015)Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved treatment efficacy and specificity. In this study, we developed ... -
A Priori Generalization Analysis of the Deep Ritz Method for Solving High Dimensional Elliptic Equations
This paper concerns the a priori generalization analysis of the Deep Ritz Method (DRM) [W. E and B. Yu, 2017], a popular neural-network-based method for solving high dimensional partial differential equations. We derive ... -
A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.
(J Am Chem Soc, 2010-04-14)The intersection of the amyloid cascade hypothesis and the implication of metal ions in Alzheimer's disease progression has sparked an interest in using metal-binding compounds as potential therapeutic agents. In the present ... -
A Quantum Kinetic Monte Carlo Method for Quantum Many-body Spin Dynamics
(2017-11-30)We propose a general framework of quantum kinetic Monte Carlo algorithm, based on a stochastic representation of a series expansion of the quantum evolution. Two approaches have been developed in the context of quantum many-body ... -
A quasinonlocal coupling method for nonlocal and local diffusion models
(2017-04-23)In this paper, we extend the idea of "geometric reconstruction" to couple a nonlocal diffusion model directly with the classical local diffusion in one dimensional space. This new coupling framework removes interfacial ...
