Browsing Duke Scholarly Works by Affiliation of Duke Author(s) "Medicine, Infectious Diseases"
Now showing items 1-20 of 313
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A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study.
(The Lancet. Infectious diseases, 2020-09-24)BACKGROUND:Early and accurate identification of individuals with viral infections is crucial for clinical management and public health interventions. We aimed to assess the ability of transcriptomic biomarkers to identify ... -
A Case of Influenza A (H3N2) Complicated by Community-Acquired Pneumonia and Death in a Young Healthy Adult during the 2013-2014 Season.
(Front Public Health, 2017)With multiple available vaccines and antivirals, seasonal influenza A is typically a self-limited acutely debilitating illness in young healthy adults. Here, we illustrate unexpected morbidity and mortality in a relatively ... -
A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples.
(Genome Res, 2014-07)Unbiased next-generation sequencing (NGS) approaches enable comprehensive pathogen detection in the clinical microbiology laboratory and have numerous applications for public health surveillance, outbreak investigation, ... -
A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.
(Nature communications, 2018-10-24)The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine ... -
A Decade On: Systematic Review of ClinicalTrials.gov Infectious Disease Trials, 2007-2017.
(Open forum infectious diseases, 2019-06)Background:Registration of interventional trials of Food and Drug Administration-regulated drug and biological products and devices became a legal requirement in 2007; the vast majority of these trials are registered in ... -
A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting.
(BMC Infect Dis, 2014-02-13)BACKGROUND: Humans vary in their susceptibility to acquiring Staphylococcus aureus infection, and research suggests that there is a genetic basis for this variability. Several recent genome-wide association studies (GWAS) ... -
A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
(Open Forum Infect Dis, 2016-01)Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ... -
A host gene expression approach for identifying triggers of asthma exacerbations.
(PloS one, 2019-01)RATIONALE:Asthma exacerbations often occur due to infectious triggers, but determining whether infection is present and whether it is bacterial or viral remains clinically challenging. A diagnostic strategy that clarifies ... -
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ... -
A Mini Review of the Zoonotic Threat Potential of Influenza Viruses, Coronaviruses, Adenoviruses, and Enteroviruses.
(Frontiers in public health, 2018-01)During the last two decades, scientists have grown increasingly aware that viruses are emerging from the human-animal interface. In particular, respiratory infections are problematic; in early 2003, World Health Organization ... -
A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies.
(Frontiers in microbiology, 2018-01)Background: Acute respiratory infections (ARIs) are the leading indication for antibacterial prescriptions despite a viral etiology in the majority of cases. The lack of available diagnostics to discriminate viral and bacterial ... -
A Multicountry Molecular Analysis of Salmonella enterica Serovar Typhi With Reduced Susceptibility to Ciprofloxacin in Sub-Saharan Africa.
(Clin Infect Dis, 2016-03-15)BACKGROUND: Salmonella enterica serovar Typhi is a predominant cause of bloodstream infections in sub-Saharan Africa (SSA). Increasing numbers of S. Typhi with resistance to ciprofloxacin have been reported from different ... -
A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP).
(BMC Med, 2016-03-23)BACKGROUND: The standard 6-month four-drug regimen for the treatment of drug-sensitive tuberculosis has remained unchanged for decades and is inadequate to control the epidemic. Shorter, simpler regimens are urgently needed ... -
A Novel Approach to Practice-Based Learning and Improvement Using a Web-Based Audit and Feedback Module.
(Journal of Graduate Medical Education, 2014-09)Systematically engaging residents in large programs in quality improvement (QI) is challenging.To coordinate a shared QI project in a large residency program using an online tool.A web-based QI tool guided residents through ... -
A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania.
(BMC Infect Dis, 2014-02-20)BACKGROUND: Routine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care ... -
A randomized Phase 2 trial of telavancin versus standard therapy in patients with uncomplicated Staphylococcus aureus bacteremia: the ASSURE study.
(BMC Infect Dis, 2014-05-23)BACKGROUND: Staphylococcus aureus bacteremia is a common infection associated with significant morbidity and mortality. Telavancin is a bactericidal lipoglycopeptide active against Gram-positive pathogens, including ... -
A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis.
(N Engl J Med, 2018-03-16)BACKGROUND: Talaromyces marneffei infection is a major cause of human immunodeficiency virus (HIV)-related death in South and Southeast Asia. Guidelines recommend initial treatment with amphotericin B deoxycholate, but this ... -
A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans.
(Frontiers in Cellular and Infection Microbiology, 2018-01)Gti1/Pac2 transcription factors occur exclusively in fungi and their roles vary according to species, including regulating morphological transition and virulence, mating and secondary metabolism. Many of these functions ... -
Accessibility, availability and affordability of anti-malarials in a rural district in Kenya after implementation of a national subsidy scheme.
(Malar J, 2011-10-26)BACKGROUND: Poor access to prompt and effective treatment for malaria contributes to high mortality and severe morbidity. In Kenya, it is estimated that only 12% of children receive anti-malarials for their fever within ... -
Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases.
(Clin Infect Dis, 2010-06-01)We describe 3 cases of daptomycin-induced pulmonary toxic effects that are consistent with drug-induced acute eosinophilic pneumonia. Patients presented similarly with dyspnea, cough, hypoxia, and diffuse ground-glass opacities ...
