Browsing Duke Scholarly Works by Affiliation of Duke Author(s) "Surgery, Abdominal Transplant Surgery"
Now showing items 1-20 of 21
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Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization.
(American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020-07-13)We have previously shown that acute cytomegalovirus (CMV) infection disrupts the induction of transplantation tolerance. However, what impact acute CMV infection would have on the maintenance of established tolerance and ... -
Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
(Am J Transplant, 2014-01)De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti-CD3 immunotoxin combined with ... -
Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.
(Stem cells (Dayton, Ohio), 2016-09)We have previously demonstrated that cryopreservation and thawing lead to altered Mesenchymal stromal cells (MSC) functionalities. Here, we further analyzed MSC's fitness post freeze-thaw. We have observed that thawed MSC ... -
Cultured thymus tissue implementation promotes donor-specific tolerance to allogeneic heart transplants.
(JCI insight, 2020-04-30)Eighty-six infants born without a thymus have been treated with allogeneic cultured thymus tissue implantation (CTTI). These infants, who lack T cells and are profoundly immunodeficient at birth, after CTTI from an unmatched ... -
Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.
(Am J Transplant, 2012-09)Chronic allograft rejection is a major impediment to long-term transplant success. Humoral immune responses to alloantigens are a growing clinical problem in transplantation, with mounting evidence associating alloantibodies ... -
Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.
(Transplantation, 2015-12)BACKGROUND: Blocking leukocyte function-associated antigen (LFA)-1 in organ transplant recipients prolongs allograft survival. However, the precise mechanisms underlying the therapeutic potential of LFA-1 blockade in preventing ... -
Interleukin-15 receptor blockade in non-human primate kidney transplantation.
(Transplantation, 2010-04-27)BACKGROUND: Interleukin (IL)-15 is a chemotactic factor to T cells. It induces proliferation and promotes survival of activated T cells. IL-15 receptor blockade in mouse cardiac and islet allotransplant models has led to ... -
Kidney Donor Profile Index Is a Reliable Alternative to Liver Donor Risk Index in Quantifying Graft Quality in Liver Transplantation.
(Transplantation direct, 2019-12)Background:The most established metric for estimating graft survival from donor characteristics in liver transplantation is the liver donor risk index (LDRI). The LDRI is calculated from donor and transplant-related variables, ... -
Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.
(Am J Transplant, 2015-03)Depletional strategies directed toward achieving tolerance induction in organ transplantation have been associated with an increased incidence and risk of antibody-mediated rejection (AMR) and graft injury. Our clinical ... -
Organ donation during the coronavirus pandemic: an evolving saga in uncharted waters.
(Transplant international : official journal of the European Society for Organ Transplantation, 2020-04-12) -
Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.
(Am J Transplant, 2012-10)Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody-mediated mechanisms during CR are poorly ... -
Perioperative Challenges in Liver Transplantation for a Patient With Acute Intermittent Porphyria.
(Journal of cardiothoracic and vascular anesthesia, 2017-11-28) -
Prevention trumps treatment of antibody-mediated transplant rejection.
(J Clin Invest, 2010-04)Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and ... -
Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.
(J Immunol, 2011-10-15)Grafts can be rejected even when matched for MHC because of differences in the minor histocompatibility Ags (mH-Ags). H4- and H60-derived epitopes are known as immunodominant mH-Ags in H2(b)-compatible BALB.B to C57BL/6 ... -
Psychosocial Assessment of Candidates for Transplantation (PACT) Score Identifies High Risk Patients in Pediatric Renal Transplantation.
(Frontiers in pediatrics, 2019-01)Background: Currently, there is no standardized approach for determining psychosocial readiness in pediatric transplantation. We examined the utility of the Psychosocial Assessment of Candidates for Transplantation (PACT) ... -
Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.
(Am J Transplant, 2016-09)Previously, we demonstrated that alemtuzumab induction with rapamycin as sole maintenance therapy is associated with an increased incidence of humoral rejection in human kidney transplant patients. To investigate the role ... -
The role of B cells in solid organ transplantation.
(Semin Immunol, 2012-04)The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning ... -
The TALKS study to improve communication, logistical, and financial barriers to live donor kidney transplantation in African Americans: protocol of a randomized clinical trial.
(BMC Nephrol, 2015-10-09)BACKGROUND: Live donor kidney transplantation (LDKT), an optimal therapy for many patients with end-stage kidney disease, is underutilized, particularly by African Americans. Potential recipient difficulties initiating and ... -
Toll-like receptor activation as a biomarker in traumatically injured patients
(Journal of Surgical Research, 2018-11-01)© 2018 Elsevier Inc. Background: Surgical insult and trauma have been shown to cause dysregulation of the immune and inflammatory responses. Interaction of damage-associated molecular patterns (DAMPs) with toll-like receptors ...
