Browsing Duke Scholarly Works by Submit Date
Now showing items 1-20 of 15592
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Universal Digital High Resolution Melt for the detection of pulmonary mold infections.
(bioRxiv, 2023-11-09)BACKGROUND: Invasive mold infections (IMIs) such as aspergillosis, mucormycosis, fusariosis, and lomentosporiosis are associated with high morbidity and mortality, particularly in immunocompromised patients, with mortality ... -
Risk for opioid abuse is diminished by inhibiting aldehyde dehydrogenase-2 (ALDH-2) in rats
(Journal of Drug and Alcohol Research, 2019-01-01)Significant opiate addiction is known to follow prescribed opiate use for pain. There is a serious unmet need for non-addicting medications to prevent subsequent opiate addiction after a short period of opioid treatment ... -
The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene: Effects on Cholinergic and Serotonergic Systems.
(Toxicological sciences : an official journal of the Society of Toxicology, 2019-01)Tobacco smoke contains polycyclic aromatic hydrocarbons (PAHs) in addition to nicotine. We compared the developmental neurotoxicity of nicotine to that of the PAH archetype, benzo[a]pyrene (BaP), and also evaluated the effects ... -
α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.
(European journal of pharmacology, 2019-02)Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. Sazetidine-A has been shown in our previous studies to significantly ... -
Corrigendum to "The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems".
(Toxicological sciences : an official journal of the Society of Toxicology, 2019-03)The correct units in Tables S3, S5, and S6 are "fmol/mg protein," whereas no units should be specified in Table S4, which presents data as a ratio. -
Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD).
(The Journal of endocrinology, 2019-03)Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent ... -
Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.
(Pharmacology, biochemistry, and behavior, 2019-04)Sazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly ... -
Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.
(Neurotoxicology and teratology, 2019-07)Developmental neurotoxicity of a wide variety of toxicants mediated via maternal exposure during gestation is very well established. In contrast, the impacts of paternal toxicant exposure on offspring neurobehavioral function ... -
Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems.
(Toxicology, 2019-08)Organophosphate pesticides are developmental neurotoxicants. We gave diazinon via osmotic minipumps implanted into dams prior to conception, with exposure continued into the second postnatal week, at doses (0.5 or 1 mg/kg/day) ... -
Chronic memantine decreases nicotine self-administration in rats.
(European journal of pharmacology, 2019-10)Neurobehavioral bases of tobacco addiction and nicotine reinforcement are complex, involving more than only nicotinic cholinergic or dopaminergic systems. Memantine is an NMDA glutamate antagonist used to improve cognitive ... -
Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences.
(Birth defects research, 2019-10)Tobacco smoke is a complex mixture that includes thousands of compounds. Previously, we have found that gestational exposure to the complex mixture of tobacco smoke extract caused long-term neurobehavioral impairments. In ... -
Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats.
(Pharmacology, biochemistry, and behavior, 2019-11)A variety of neural systems are involved in the brain bases of tobacco addiction. Animal models of nicotine addiction have helped identify a variety of interacting neural systems involved in the pathophysiology of tobacco ... -
Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the rat.
(Toxicology, 2020-01)Diazinon is a widely-used organophosphate pesticide. Pulsatile exposure to diazinon during neonatal development has previously been shown cause long-term neurobehavioral impairments in rats. However, the effects of chronic ... -
Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.
(Neurotoxicology and teratology, 2020-03)Farmers are often chronically exposed to insecticides, which may present health risks including increased risk of neurobehavioral impairment during adulthood and across aging. Experimental animal studies complement ... -
Paternal Δ9-Tetrahydrocannabinol Exposure Prior to Mating Elicits Deficits in Cholinergic Synaptic Function in the Offspring.
(Toxicological sciences : an official journal of the Society of Toxicology, 2020-04)Little attention has been paid to the potential impact of paternal marijuana use on offspring brain development. We administered Δ9-tetrahydrocannabinol (THC, 0, 2, or 4 mg/kg/day) to male rats for 28 days. Two days after ... -
Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring.
(Neurotoxicology, 2020-05)The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its ... -
Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats.
(Psychopharmacology, 2020-06)<h4>Rationale</h4>A variety of neural systems are involved in drug addiction, and some of these systems are shared across different addictive drugs. We have found several different types of drug treatments that successfully ... -
Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio).
(Naunyn-Schmiedeberg's archives of pharmacology, 2020-08)Attention deficit hyperactive disorder (ADHD) is the most common psychiatric disorder in children affecting around 11% of children 4-17 years of age (CDC 2019). Children with ADHD are widely treated with stimulant medications ... -
Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function.
(Neurotoxicology and teratology, 2020-09)Vitamin D receptor (VDR) signaling is important for optimal neurobehavioral development. Disruption of VDR signaling by environmental toxicants during early development might contribute to the etiology of behavioral dysfunction. ...
