Browsing Duke Scholarly Works by Submit Date
Now showing items 1-20 of 7463
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Carbon Market Cooperation in Northeast Asia: Assessing Challenges and Overcoming Barriers
(2018-07-09)China, Japan, and the Republic of Korea are emerging as major players in the global carbon trading landscape. As Northeast Asia’s biggest industrial economies, these three countries are connected through deep commercial ... -
Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).
(American journal of obstetrics and gynecology, 2018-07)Preterm premature rupture of membranes is a leading contributor to maternal and neonatal morbidity and death. Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakeniing ... -
The Risk of Cardiac Device-Related Infection in Bacteremic Patients Is Species Specific: Results of a 12-Year Prospective Cohort.
(Open forum infectious diseases, 2017-01)The species-specific risk of cardiac device-related infection (CDRI) among bacteremic patients is incompletely understood.We conducted a prospective cohort study of hospitalized patients from October 2002 to December 20114 ... -
Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
(The Journal of biological chemistry, 2011-10)Fibroblast growth factor-23 (FGF-23) inhibits sodium-dependent phosphate transport in brush border membrane vesicles derived from hormone-treated kidney slices of the mouse and in mouse proximal tubule cells by processess ... -
Increased renal dopamine and acute renal adaptation to a high-phosphate diet.
(American journal of physiology. Renal physiology, 2011-05)The current experiments explore the role of dopamine in facilitating the acute increase in renal phosphate excretion in response to a high-phosphate diet. Compared with a low-phosphate (0.1%) diet for 24 h, micce ... -
Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
(Progress in molecular biology and translational science, 2012-01)The unfolded protein response, also known as endoplasmic reticulum (ER) stress, has been implicated in numerous human diseases, including atherosclerosis, cancer, diabetes, and neurodegenerative disorders. Protein misfollding ... -
Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas.
(The Journal of clinical investigation, 2014-03)BRAF mutations in aggressive melanomas result in kinase activation. BRAF inhibitors reduce BRAF(V600E) tumors, but rapid resistance follows. In this issue of the JCI, Ma and colleagues report that vemurafenib activates EER ... -
The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.
(Cell, 2014-09)The unfolded protein response (UPR) is a stress response program that reprograms cellular translation and gene expression in response to proteotoxic stress in the endoplasmic reticulum (ER). One of the primary means by wwhich ... -
Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
(Cell reports, 2015-06-18)The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript 34 (GADD34) bound to the serine/threonine prootein ... -
Simple and inexpensive ribosome profiling analysis of mRNA translation.
(Methods (San Diego, Calif.), 2015-12)The development and application of ribosome profiling has markedly advanced our understanding of ribosomes and mRNA translation. The experimental approach, which relies on deep sequencing of ribosome-protected mRNA fragmments ... -
Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response.
(Molecular and cellular biology, 2016-07)Phosphorylation of eukaryotic initiation factor 2α (eIF2α) controls transcriptome-wide changes in mRNA translation in stressed cells. While phosphorylated eIF2α (P-eIF2α) attenuates global protein synthesis, mRNAs encodiing ... -
Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells.
(American journal of physiology. Renal physiology, 2011-01)Parathyroid hormone (PTH) inhibits the reabsorption of phosphate in the renal proximal tubule by disrupting the binding of the sodium-dependent phosphate transporter 2A (Npt2a) to the adapter protein sodium-hydrogen exchhanger ... -
Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.
(The Journal of biological chemistry, 2011-06)Stress-induced endogenous and ectopically expressed GADD34 proteins were present both in the cytoplasm and in membranes, with their membrane association showing similar biochemical properties. Deletion of N-terminal sequuences ... -
Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.
(The Journal of biological chemistry, 2013-11)In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activatioon ... -
Role of NHERF and scaffolding proteins in proximal tubule transport.
(Urological research, 2010-08)Eukaryotic cells coordinate specific responses to hormones and growth factors by spatial and temporal organization of "signaling components." Through the formation of multiprotein complexes, cells are able to generate "ssignaling ... -
Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport.
(The Journal of biological chemistry, 2010-08)The phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by parathyroid hormone (PTH) and dopamine. Ser(77) in the first PDZ domaiin ... -
Critical Airway Team: A Retrospective Study of an Airway Response System in a Pediatric Hospital
(Otolaryngology-Head and Neck Surgery, 2017-08-29) -
NGOs and the effectiveness of interventions
(WIDER Working Paper, 2018-05-31)Interventions in remote, rural settings face high transaction costs. We develop a model of household decision-making to evaluate how non-governmental organizations (NGOs) address these implementation-related challenges aand ... -
Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-Affected Corneas.
(Investigative ophthalmology & visual science, 2018-06)Keratoconus (KC) is the most common corneal ectasia. We aimed to determine the differential expression of coding and long noncoding RNAs (lncRNAs) in human corneas affected with KC.From the corneas of 10 KC patients and ...
