Browsing Duke Scholarly Works by Subject "E2F1 Transcription Factor"
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Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. (Proc Natl Acad Sci U S A, 2007-12-26)Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream ...