Now showing items 1-2 of 2

    • Angiopoietin-1 is required for Schlemm's canal development in mice and humans. 

      Azmanov, Dimitar N; Bradfield, Yasmin S; Craig, Jamie E; Feng, Liang; Finzi, Simone; Hewitt, Alex W; Javadiyan, Shari; ... (26 authors) (The Journal of clinical investigation, 2017-12)
      Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously ...
    • Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. 

      Chen, Ming; Zhang, Jiangwen; Berger, Alice H; Diolombi, Moussa S; Ng, Christopher; Fung, Jacqueline; Bronson, Roderick T; ... (12 authors) (The Journal of clinical investigation, 2019-01)
      Recurrent broad-scale heterozygous deletions are frequently observed in human cancer. Here we tested the hypothesis that compound haploinsufficiency of neighboring genes at chromosome 8p promotes tumorigenesis. By targeting ...