Browsing Duke Scholarly Works by Subject "P-Glycoproteins"

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Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.

Chan, IS; Choi, S; Diehl, Anna Mae; Feuerlein, S; Guy, Cynthia D; Jung, Y; Karaca, GF; ... (18 authors) (PLoS One, 2011)

OBJECTIVE: Chronic fibrosing liver injury is a major risk factor for hepatocarcinogenesis in humans. Mice with targeted deletion of Mdr2 (the murine ortholog of MDR3) develop chronic fibrosing liver injury. Hepatocellular ...