Browsing Duke Scholarly Works by Subject "excitatory synapses"
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Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. (J Neurosci, 2014-07-09)Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated ...