Browsing Duke Scholarly Works by Subject "p53"
Now showing items 1-5 of 5
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Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice.
(Front Oncol, 2013)PURPOSE: Non-small cell lung cancers (NSCLC) are a heterogeneous group of carcinomas harboring a variety of different gene mutations. We have utilized two distinct genetically engineered mouse models of human NSCLC ... -
Dysregulation of Cell Survival in Diffuse Large B Cell Lymphoma: Mechanisms and Therapeutic Targets.
(Frontiers in Oncology, 2019-01)Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoma worldwide, representing 30-40% of non-Hodgkin lymphomas, and is clinically aggressive. Although more than half of patients with DLBCL are cured by ... -
The Intersection of DNA Damage Response and Ferroptosis-A Rationale for Combination Therapeutics.
(Biology, 2020-07-23)Ferroptosis is a novel form of iron-dependent cell death characterized by lipid peroxidation. While the importance and disease relevance of ferroptosis are gaining recognition, much remains unknown about its interaction ... -
The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells.
(Pharmaceuticals (Basel, Switzerland), 2021-09-21)Elevated expression of placenta-specific protein 1 (PLAC1) is associated with the increased proliferation and invasiveness of a variety of human cancers, including ovarian cancer. Recent studies have shown that the tumor ...
