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Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
Liability issues for data monitoring committee members.
(Clin Trials, 2004)
In randomized clinical trials, a data monitoring committee (DMC) is often appointed
to review interim data to determine whether there is early convincing evidence of
intervention benefit, lack of benefit or harm to study ...
Issues in regulatory guidelines for data monitoring committees.
(Clin Trials, 2004)
As clinical trials have emerged as the major research method for evaluating new interventions,
the process for monitoring intervention safety and benefit has also evolved. The Data
Monitoring Committee (DMC) has become the ...
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
(Circulation, 2001-03-06)
BACKGROUND: Genetic manipulation to reverse molecular abnormalities associated with
dysfunctional myocardium may provide novel treatment. This study aimed to determine
the feasibility and functional consequences of in vivo ...
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization
and desensitization of G-protein-coupled receptors (GPCRs) and also participates in
the process of heterologous desensitization between ...
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
(Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein
kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide
regulatory protein (G(s)) to inhibitory guanine nucleotide ...
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
(Proc Natl Acad Sci U S A, 2000-02-01)
Recently, we identified a GTPase-activating protein for the ADP ribosylation factor
family of small GTP-binding proteins that we call GIT1. This protein initially was
identified as an interacting partner for the G protein-coupled ...
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
(Proc Natl Acad Sci U S A, 2000-02-15)
Acting through a number of distinct pathways, many G protein-coupled receptors (GPCRs)
activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein
kinase (MAPK) cascade. Recently, it has been shown ...
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
(Circ Res, 2000-01-07)
G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled
receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization.
In vivo analysis of GRK substrate selectivity has ...
The annual ASCI meeting: does nostalgia have a future?
(J Clin Invest, 2008-04)
For many academic physician-scientists, the yearly Tri-Societies meeting of the ASCI,
AAP, and AFCR during the 1960s, '70s, and '80s was an annual rite of spring and the
focal point of the academic year. In this brief essay, ...