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Now showing items 1-10 of 31
Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya.
(PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular
disease burden. The clinical profile and outcomes of AF patients with valvular heart
diseases in sub-Saharan Africa (SSA) have not ...
Steps to Health employee weight management randomized control trial: short-term follow-up results.
(J Occup Environ Med, 2015-02)
OBJECTIVE: To present the short-term follow-up findings of the Steps to Health study,
a randomized trial to evaluate the effectiveness of two employee weight management
programs offered within Duke University and the Health ...
Torsemide versus furosemide in heart failure patients: insights from Duke University Hospital.
(J Cardiovasc Pharmacol, 2015-05)
Furosemide has historically been the primary loop diuretic in heart failure patients
despite data suggesting potential advantages with torsemide. We used the Duke Echocardiography
Lab Database to investigate patients admitted ...
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
(PLoS One, 2012)
OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma
metabolic intermediates in response to a mixed meal, suggestive of changes in the
capacity to adapt fuel oxidation to fuel availability or ...
Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.
(PloS one, 2019-01)
BACKGROUND:The heart is a metabolically active organ, and plasma acylcarnitines are
associated with long-term risk for myocardial infarction. We hypothesized that myocardial
ischemia from cardiac stress testing will produce ...
Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.
(J Infect Dis, 2016-05-01)
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause
of diarrhea. Though usually self-limited, it can be severe and debilitating. Little
is known about the host transcriptional response to infection. ...
Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function.
(J Am Soc Nephrol, 2017-10)
Efficacy of statin-based therapies in reducing cardiovascular mortality in individuals
with CKD seems to diminish as eGFR declines. The strongest evidence supporting the
cardiovascular benefit of statins in individuals with ...
Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.
(Diabetes Care, 2011-01)
OBJECTIVE: To understand relationships between exercise training-mediated improvements
in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic
intermediates, hormones, and inflammatory mediators. ...
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)
There is great potential for host-based gene expression analysis to impact the early
diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted
the challenges and limitations of traditional ...
Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting
that respiratory viral infection may induce biologic pathways that contribute to MI.
We tested the hypotheses that 1) a validated ...