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Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
(Scientific reports, 2015-01)
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway
may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1
and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
(Journal of cellular and molecular medicine, 2016-04)
Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma
(ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers,
including ESCC. Some single nucleotide polymorphisms ...
Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis
pathway and plays a crucial role in cancer development and progression. However, few
studies have evaluated associations between functional ...
Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated
cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially
functional single nucleotide ...
Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations.
(PloS one, 2012-01)
BACKGROUND: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important
role in regulating DNA excision repair; its functional single nucleotide polymorphisms
(SNPs) may alter DNA repair capacity and thus ...
A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
(Scientific reports, 2016-01-28)
AKT is an important signal transduction protein that plays a crucial role in cancer
development. Therefore, we evaluated associations between single nucleotide polymorphisms
(SNPs) in the AKT promoter region and gastric ...
PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.
(Oncotarget, 2016-02)
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen
(PSA), was identified as a gene involved in cell adhesion and proliferation. The associations
between the PSCA rs2294008 and rs2976392 ...
Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.
(Oncotarget, 2016-12)
Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize
that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and
we genotyped five potentially functional single ...
Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.
(PloS one, 2012-01)
BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune
and pro-inflammatory response, and genetic polymorphisms of candidate genes involved
in autoimmune and pro-inflammatory response ...