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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
(Circ Res, 2000-01-07)
G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled
receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization.
In vivo analysis of GRK substrate selectivity has ...