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Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

Pierce, KL; Maudsley, S; Daaka, Y; Luttrell, LM; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 2000-02-15)

Acting through a number of distinct pathways, many G protein-coupled receptors (GPCRs) activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) cascade. Recently, it has been shown ...