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The Risk of Cardiac Device-Related Infection in Bacteremic Patients Is Species Specific: Results of a 12-Year Prospective Cohort.
(Open forum infectious diseases, 2017-01)
The species-specific risk of cardiac device-related infection (CDRI) among bacteremic
patients is incompletely understood.We conducted a prospective cohort study of hospitalized
patients from October 2002 to December 2014 ...
Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia.
(Open forum infectious diseases, 2018-03)
Penicillin allergy frequently impacts antibiotic choice. As beta-lactams are superior
to vancomycin in treating methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia,
we examined the effect of reported penicillin ...
Geographic expansion of Lyme disease in Michigan, 2000-2014
(Open Forum Infectious Diseases, 2017-01-01)
© The Author 2017.Background. Most Lyme disease cases in the Midwestern United States
are reported in Minnesota and Wisconsin. In recent years, however, a widening geographic
extent of Lyme disease has been noted with evidence ...
MASTERMIND: Bringing Microbial Diagnostics to the Clinic.
(Clin Infect Dis, 2017-02-01)
New diagnostics are urgently needed to address emerging antimicrobial resistance.
The Antibacterial Resistance Leadership Group proposes a strategy called MASTERMIND
(Master Protocol for Evaluating Multiple Infection Diagnostics) ...
A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting.
(BMC Infect Dis, 2014-02-13)
BACKGROUND: Humans vary in their susceptibility to acquiring Staphylococcus aureus
infection, and research suggests that there is a genetic basis for this variability.
Several recent genome-wide association studies (GWAS) ...
Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing.
(Open Forum Infect Dis, 2016-09)
We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus
that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing
assay. This technology shows great promise ...
A randomized Phase 2 trial of telavancin versus standard therapy in patients with uncomplicated Staphylococcus aureus bacteremia: the ASSURE study.
(BMC Infect Dis, 2014-05-23)
BACKGROUND: Staphylococcus aureus bacteremia is a common infection associated with
significant morbidity and mortality. Telavancin is a bactericidal lipoglycopeptide
active against Gram-positive pathogens, including ...
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal
disease and hemodialysis (HD) on patient response during critical illness. To achieve
this, we examined the metabolome, proteome, ...
Bonds between fibronectin and fibronectin-binding proteins on Staphylococcus aureus and Lactococcus lactis.
(Langmuir, 2010-07-06)
Bacterial cell-wall-associated fibronectin binding proteins A and B (FnBPA and FnBPB)
form bonds with host fibronectin. This binding reaction is often the initial step
in prosthetic device infections. Atomic force microscopy ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...