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LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
(Journal of thoracic oncology : official publication of the International Association
for the Study of Lung Cancer, 2014-06)
Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer,
and understanding the pathways and phenotypes altered as a consequence will aid the
development of targeted therapeutic strategies. Gene ...
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
(The Journal of clinical investigation, 2016-07)
Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause
of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous
humor outflow structures of the eye result in elevated ...
Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
(PloS one, 2012-01)
It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic
encephalopathy (HIE). Many women use some form of analgesia during childbirth and
some anesthetic agents have been shown to be neuroprotective ...
Role of NHERF and scaffolding proteins in proximal tubule transport.
(Urological research, 2010-08)
Eukaryotic cells coordinate specific responses to hormones and growth factors by spatial
and temporal organization of "signaling components." Through the formation of multiprotein
complexes, cells are able to generate "signaling ...
A neural network-based method for spectral distortion correction in photon counting x-ray CT.
(Physics in medicine and biology, 2016-08)
Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for
measuring material composition based on energy dependent x-ray attenuation. Spectral
CT is especially suited for imaging with K-edge contrast ...
Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
(Cell reports, 2015-06-18)
The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress
response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript
34 (GADD34) bound to the serine/threonine protein ...
Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2.
(Cancer research, 2008-10)
Black cohosh is an herbal extract that is often used as an alternative to estrogen-based
replacement therapies to treat hot flushes that frequently accompany the transition
to menopause. Although cancer-free women as well ...
Translational toxicology: a developmental focus for integrated research strategies.
(BMC pharmacology & toxicology, 2013-01)
BACKGROUND: Given that toxicology studies the potential adverse effects of environmental
exposures on various forms of life and that clinical toxicology typically focuses
on human health effects, what can and should the ...
Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.
(Science signaling, 2017-05-16)
Placental activation of the renin-angiotensin system (RAS) plays a key role in the
pathogenesis of preeclampsia. Reactive oxygen species (ROS) are thought to affect
placental angiogenesis, which is critical for preventing ...
The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction.
(The Journal of urology, 2016-05)
While bladder outlet obstruction is well established to elicit an inflammatory reaction
in the bladder that leads to overactive bladder and fibrosis, little is known about
the mechanism by which this is initiated. NLRs (NOD-like ...