Now showing items 1-10 of 42
Using decision analysis to improve malaria control policy making.
(Health Policy, 2009-10)
Malaria and other vector-borne diseases represent a significant and growing burden in many tropical countries. Successfully addressing these threats will require policies that expand access to and use of existing control ...
Bonds between fibronectin and fibronectin-binding proteins on Staphylococcus aureus and Lactococcus lactis.
Bacterial cell-wall-associated fibronectin binding proteins A and B (FnBPA and FnBPB) form bonds with host fibronectin. This binding reaction is often the initial step in prosthetic device infections. Atomic force microscopy ...
Metabolomic derangements are associated with mortality in critically ill adult patients.
(PLoS One, 2014)
OBJECTIVE: To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU) mortality in adults. RATIONALE: Comprehensive metabolomic profiling of plasma at ICU admission to identify biomarkers associated with ...
Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections.
(PLoS Pathog, 2016-01)
Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014.
(Open Forum Infect Dis, 2015-12)
Background. The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising ...
Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance.
(PLoS One, 2009)
BACKGROUND: Most information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus ...
An integrated transcriptome and expressed variant analysis of sepsis survival and death.
(Genome Med, 2014)
BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ...
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ...
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...
Patient detection of a drug dispensing error by use of physician-provided drug samples.