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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately
2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally
do not become detectable until 12 weeks ...
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.
(Br J Cancer, 2009-12-15)
BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant
glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including
27 with glioblastoma (GBM) and 32 with grade ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages.
(Arthritis Res Ther, 2009)
INTRODUCTION: Certain amino acids within proteins have been reported to change from
the L form to the D form over time. This process is known as racemization and is most
likely to occur in long-lived low-turnover tissues ...
Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate.
(Arthritis Res Ther, 2009)
INTRODUCTION: Aging proteins undergo non-enzymatic post-translational modification,
including isomerization and racemization. We hypothesized that cartilage with many
long-lived components could accumulate non-enzymatically ...
Prognostic biomarkers in individuals with prevalent coronary heart disease.
(Dis Markers, 2009)
Coronary disease is the leading killer of individuals worldwide and a leading cause
of healthcare expenditure. On a global scale, ischemic heart disease kills over 6
million individuals each year and is projected by the ...
Early versus delayed fixed dose combination abacavir/lamivudine/zidovudine in patients with HIV and tuberculosis in Tanzania.
(AIDS Res Hum Retroviruses, 2009-12)
Fixed dose combination abacavir/lamivudine/zidovudine (ABC/3TC/ZDV) among HIV-1 and
tuberculosis (TB)-coinfected patients was evaluated and outcomes between early vs.
delayed initiation were compared. In a randomized, pilot ...
Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance.
(PLoS One, 2009)
BACKGROUND: Most information on invasive Staphylococcus aureus infections comes from
temperate countries. There are considerable knowledge gaps in epidemiology, treatment,
drug resistance and outcome of invasive S. aureus ...
Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South Africa.
(Subst Abuse Treat Prev Policy, 2009-05-27)
BACKGROUND: This study examined cross-sectional data collected from substance-using
female sex workers (FSW) and non-sex workers (non-SW) in Pretoria, South Africa, who
entered a randomized controlled trial. METHODS: Women ...