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    Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. 

    Allgood, S; Amos, JD; Cohen, MS; Eron, JJ; Goepfert, Paul A; Gurley, TC; Haynes, Barton Ford; ... (25 authors) (PLoS Med, 2009-07-07)
    BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...
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    Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. 

    Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, Sridharan; Herndon, James Emmett II; Marcello, JE; ... (13 authors) (Br J Cancer, 2009-12-15)
    BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including 27 with glioblastoma (GBM) and 32 with grade ...
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    Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 

    Connelly, Jessica J; Crosslin, DR; Crossman, DC; Freedman, NJ; Ginsburg, Geoffrey Steven; Goldschmidt-Clermont, PJ; Granger, CB; ... (22 authors) (PLoS Genet, 2009-01)
    Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, ...
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    Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages. 

    Byers, SS; Kraus, Virginia Byers; Stabler, Thomas; Zura, Robert Douglas (Arthritis Res Ther, 2009)
    INTRODUCTION: Certain amino acids within proteins have been reported to change from the L form to the D form over time. This process is known as racemization and is most likely to occur in long-lived low-turnover tissues ...
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    Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate. 

    Barr, D; Bolognesi, Michael Paul; Catterall, JB; Kraus, Virginia Byers; Zura, Robert Douglas (Arthritis Res Ther, 2009)
    INTRODUCTION: Aging proteins undergo non-enzymatic post-translational modification, including isomerization and racemization. We hypothesized that cartilage with many long-lived components could accumulate non-enzymatically ...
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    Prognostic biomarkers in individuals with prevalent coronary heart disease. 

    Halim, SA; Newby, Laura Kristin (Dis Markers, 2009)
    Coronary disease is the leading killer of individuals worldwide and a leading cause of healthcare expenditure. On a global scale, ischemic heart disease kills over 6 million individuals each year and is projected by the ...
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    Early versus delayed fixed dose combination abacavir/lamivudine/zidovudine in patients with HIV and tuberculosis in Tanzania. 

    Bartlett, John A; Crump, John Andrew; Kiwera, RA; Moon, AM; Ole-Nguyaine, S; Ramadhani, HO; Shao, HJ; ... (11 authors) (AIDS Res Hum Retroviruses, 2009-12)
    Fixed dose combination abacavir/lamivudine/zidovudine (ABC/3TC/ZDV) among HIV-1 and tuberculosis (TB)-coinfected patients was evaluated and outcomes between early vs. delayed initiation were compared. In a randomized, pilot ...
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    Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance. 

    Becher, H; Chierakul, W; Day, NP; Fowler, Vance Garrison Jr; Hongsuwan, M; Limmathurotsakul, D; Mahavanakul, W; ... (16 authors) (PLoS One, 2009)
    BACKGROUND: Most information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus ...
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    Evaluation and recommendations on good clinical laboratory practice guidelines for phase I-III clinical trials. 

    Cleland, N; Cox, J; Denny, Thomas Norton; Hural, J; Needham, Leila K; Ozaki, Dan; Rodriguez-Chavez, IR; ... (12 authors) (PLoS Med, 2009-05-26)
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    Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South Africa. 

    Wechsberg, WM; Wu, L-T; Zule, WA; Parry, CD; Browne, FA; Luseno, WK; Kline, T; ... (8 authors) (Subst Abuse Treat Prev Policy, 2009-05-27)
    BACKGROUND: This study examined cross-sectional data collected from substance-using female sex workers (FSW) and non-sex workers (non-SW) in Pretoria, South Africa, who entered a randomized controlled trial. METHODS: Women ...
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    AuthorWei, Qingyi (3)Ajani, Jaffer A (2)Becher, H (2)Chierakul, W (2)Day, NP (2)Fowler, Vance Garrison Jr (2)Guan, Xiaoxiang (2)Haynes, Barton Ford (2)Hongsuwan, M (2)Kraus, Virginia Byers (2)... View MoreDate Issued
    2009 (18)
    TypeJournal article (18)SubjectHumans (16)Middle Aged (9)Adult (8)Male (8)Female (7)Aged (6)Aged, 80 and over (4)Genotype (4)Adolescent (3)Alleles (3)... View MoreAffiliation of Duke Author(s)
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    School of Medicine (18)Basic Science Departments (13)Duke Cancer Institute (10)Duke Clinical Research Institute (7)Molecular Genetics and Microbiology (7)Faculty (6)... View More