Now showing items 1-9 of 9
Liability issues for data monitoring committee members.
(Clin Trials, 2004)
In randomized clinical trials, a data monitoring committee (DMC) is often appointed to review interim data to determine whether there is early convincing evidence of intervention benefit, lack of benefit or harm to study ...
Issues in regulatory guidelines for data monitoring committees.
(Clin Trials, 2004)
As clinical trials have emerged as the major research method for evaluating new interventions, the process for monitoring intervention safety and benefit has also evolved. The Data Monitoring Committee (DMC) has become the ...
A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation.
(Health Qual Life Outcomes, 2004-05-06)
BACKGROUND: Anticoagulation can reduce quality of life, and different models of anticoagulation management might have different impacts on satisfaction with this component of medical care. Yet, to our knowledge, there are ...
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between ...
Physical function and associations with diet and exercise: Results of a cross-sectional survey among elders with breast or prostate cancer.
(Int J Behav Nutr Phys Act, 2004-10-29)
BACKGROUND: Functional decline threatens independent living and is common among individuals diagnosed with cancer, especially those who are elderly. The purpose of this study was to explore whether dietary and exercise practices ...
Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.
(J Clin Invest, 2004-05)
Antibodies specific for the beta(1)-adrenergic receptor are found in patients with chronic heart failure of various etiologies. From work presented in this issue of the JCI, we can now infer that these antibodies actually ...
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
(Proc Natl Acad Sci U S A, 2004-08-10)
Epithelial Na(+) channels mediate the transport of Na across epithelia in the kidney, gut, and lungs and are required for blood pressure regulation. They are inhibited by ubiquitin protein ligases, such as Nedd4 and Nedd4-2, ...
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
(Journal of Clinical Investigation, 2004-05-15)
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
(J Neurosci, 2004-05-12)
Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using a phosphoselective antibody [kappa opioid receptor ...