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Now showing items 1-10 of 72
PhenX RISING: real world implementation and sharing of PhenX measures.
(BMC Med Genomics, 2014-03-20)
BACKGROUND: The purpose of this manuscript is to describe the PhenX RISING network
and the site experiences in the implementation of PhenX measures into ongoing population-based
genomic studies. METHODS: Eighty PhenX measures ...
Steps to Health employee weight management randomized control trial: short-term follow-up results.
(J Occup Environ Med, 2015-02)
OBJECTIVE: To present the short-term follow-up findings of the Steps to Health study,
a randomized trial to evaluate the effectiveness of two employee weight management
programs offered within Duke University and the Health ...
Detection of Bartonella species in the blood of veterinarians and veterinary technicians: a newly recognized occupational hazard?
(Vector Borne Zoonotic Dis, 2014-08)
BACKGROUND: Bartonella species are important emerging pathogens in human and veterinary
medicine. In the context of their daily activities, veterinary professionals have
frequent animal contact and arthropod exposures. Detection ...
Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.
(Hypertension, 2010-06)
High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction.
Although aerobic exercise and dietary modifications have been shown to reduce blood
pressure, no randomized trials have examined ...
The human antibody response to the surface of Mycobacterium tuberculosis.
(PLoS One, 2014)
BACKGROUND: Vaccine-induced human antibodies to surface components of Haemophilus
influenzae and Streptococcus pneumonia are correlated with protection. Monoclonal
antibodies to surface components of Mycobacterium tuberculosis ...
A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania.
(BMC Infect Dis, 2014-02-20)
BACKGROUND: Routine tuberculosis culture remains unavailable in many high-burden areas,
including Tanzania. This study sought to determine the impact of providing mycobacterial
culture results over standard of care ...
Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting
that respiratory viral infection may induce biologic pathways that contribute to MI.
We tested the hypotheses that 1) a validated ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
(J Thorac Cardiovasc Surg, 2014-04)
OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality
has been challenged. The conflicting results might have resulted from the extent of
BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.
(Am Heart J, 2015-04)
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients
with ischemic heart disease (IHD) and associated with a poorer cardiovascular prognosis.
Platelet hyperactivity is an important factor in ...