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Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting
that respiratory viral infection may induce biologic pathways that contribute to MI.
We tested the hypotheses that 1) a validated ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
(J Thorac Cardiovasc Surg, 2014-04)
OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality
has been challenged. The conflicting results might have resulted from the extent of
BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...
Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.
(J Infect Dis, 2016-05-01)
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause
of diarrhea. Though usually self-limited, it can be severe and debilitating. Little
is known about the host transcriptional response to infection. ...
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and
uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature
suggests the host's inflammatory response to the ...
Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.
(Ann Am Thorac Soc, 2016-03)
RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections
often delay initiation of effective antimicrobial therapy. New diagnostic approaches
offer potential clinical and cost-related improvements ...
Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes: study rationale, development and design.
(BMC Health Serv Res, 2012-01-18)
BACKGROUND: Type 2 diabetes is a prevalent chronic condition globally that results
in extensive morbidity, decreased quality of life, and increased health services utilization.
Lifestyle changes can prevent the development ...
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)
There is great potential for host-based gene expression analysis to impact the early
diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted
the challenges and limitations of traditional ...
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.
(PLoS Genet, 2011-08)
Exposure to influenza viruses is necessary, but not sufficient, for healthy human
hosts to develop symptomatic illness. The host response is an important determinant
of disease progression. In order to delineate host molecular ...